Role of Autologous Platelet Gel (APG) in Bone Healing: A Rabbit Study
1
Department of Innovative Technologies in Medicine & Dentistry, University of Chieti-Pescara, Via Dei Vestini, 31, 66100 Chieti, Italy
2
Director of Specialization School of Oral Surgery, Department of Innovative Technologies in Medicine & Dentistry, University of Chieti-Pescara, Via Dei Vestini, 31, 66100 Chieti, Italy
3
Department of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70121 Bari, Italy
4
Department of Basic Medical Sciences, Neurosciences and Sense Organs, “Aldo Moro” University of Bari, 70121 Bari, Italy
5
Oral Surgery Unit, University of Eastern Piedmont, Via Lanino 1, 28100 Novara, Italy
6
Dean Faculty of Medical Sciences, Albanian University, Bulevardi Zogu I, 1001 Tirana, Albania
*
Author to whom correspondence should be addressed.
Appl. Sci. 2021, 11(1), 395; https://doi.org/10.3390/app11010395
Received: 22 November 2020
/
Revised: 29 December 2020
/
Accepted: 31 December 2020
/
Published: 4 January 2021
(This article belongs to the Special Issue Non-transfusional Hemocomponents in Oral Surgery and Implantology: From Biology to the Clinic)
Purpose: The aim of the present study is to evaluate the influence and efficacy of autologous platelets on bone regeneration in a rabbit defects model. Materials and Methods: A total of 12 critical size tibial defects were produced in six New Zealand rabbits: A total of six defects were filled with autologous platelet gel (APG) and six defects were maintained as untreated controls. No membranes were used to cover the bone osteotomies. The histology and histomorphometry were performed at four weeks on retrieved samples of both groups. Results: No complications were reported in any of the animals nor for the defects produced. A significantly higher lamellar and woven bone percentage was reported for the APG group with a lower level of marrow spaces (p < 0.05). Evidence of newly formed bone was found in the superficial portion of the bone defect of APG samples where no aspects of bone resorption were observed. Conclusions: The evidence of the present research revealed that APG increases new bone formation restricted to the cortical portion and induces more rapid healing in rabbit bone defects than in untreated defects.
View Full-Text
▼
Show Figures
Figure 1
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Scarano, A.; Inchingolo, F.; Rapone, B.; Lucchina, A.G.; Qorri, E.; Lorusso, F. Role of Autologous Platelet Gel (APG) in Bone Healing: A Rabbit Study. Appl. Sci. 2021, 11, 395. https://doi.org/10.3390/app11010395
AMA Style
Scarano A, Inchingolo F, Rapone B, Lucchina AG, Qorri E, Lorusso F. Role of Autologous Platelet Gel (APG) in Bone Healing: A Rabbit Study. Applied Sciences. 2021; 11(1):395. https://doi.org/10.3390/app11010395
Chicago/Turabian StyleScarano, Antonio, Francesco Inchingolo, Biagio Rapone, Alberta G. Lucchina, Erda Qorri, and Felice Lorusso. 2021. "Role of Autologous Platelet Gel (APG) in Bone Healing: A Rabbit Study" Applied Sciences 11, no. 1: 395. https://doi.org/10.3390/app11010395
Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.
