TB Elimination Requires Discovery and Development of Transformational Agents

Round 1

Reviewer 1 Report

The proposed Commentary entitled “TB elimination requires discovery and development of transformational agents”, by Christian Lienhardt and  Mario C. Raviglione, describe the pioneer adventure of “End TB strategy”, including  positive results that have been achieved, as well as what we still need for the completition of the starting aims.

The authors indicate some ways to address such as: improve diagnostic tests; better, safer, shorter and more efficacious treatment for all forms of TB; and, finally, a vaccine highly effective, safe and able to prevent pre-exposure infection as well as reactivation.

The commentary well fit with the aim of our issue.

Accepted for publication in its form. 

Author Response

We thank the reviewers for the positive review

Reviewer 2 Report

The commentary is a well-written up-date on novel drugs and combinations of new and existing or repurposed agents, against drug-resistant and -susceptible TB.

Minor points

Line 83: add "(Nix-TB trial)" after "…(XDR-TB)..."

Line 97: use “Nix-TB trial” instead of "...Nix trial..."

Line 124: omit "dormant or" (usually, dormant is used for the mycobacterium, latent for the disease/infection)

Lines 128-130. The sentence "Further, Q203 was shown to have a good synergy with bedaquiline in the murine chronic infection model…." should be substantiated by a Reference.

Author Response

We thank the reviewer for the positive review. we have addressed his edits in the revised manuscrit.