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Open AccessArticle

The Potential of a Nanostructured Titanium Oxide Layer with Self-Assembled Monolayers for Biomedical Applications: Surface Properties and Biomechanical Behaviors

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Department of Oral Hygiene Care, Ching Kuo Institute of Management and Health, Keelung 203, Taiwan
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Department of Dentistry, Taipei Medical University-Shuang Ho Hospital, New Taipei City 235, Taiwan
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School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan
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Division of Family and Operative Dentistry, Department of Dentistry, Taipei Medical University Hospital, Taipei 110, Taiwan
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Department of Restorative Dentistry, Health Science Center, College of Dentistry, University of Tennessee, Tennessee, TN 38163, USA
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Dental Department of Wan-Fang Hospital, Taipei Medical University, Taipei 116, Taiwan
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Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Hasanuddin University, Makassar 90245, Indonesia
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School of Dental Technology, Taipei Medical University, Taipei 110, Taiwan
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School of Dentistry, Health Sciences University of Hokkaido, Hokkaido 061-0293, Japan
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School of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan
*
Authors to whom correspondence should be addressed.
Co-First author: Ta-Sen Huang.
Appl. Sci. 2020, 10(2), 590; https://doi.org/10.3390/app10020590
Received: 21 November 2019 / Revised: 24 December 2019 / Accepted: 6 January 2020 / Published: 14 January 2020
(This article belongs to the Special Issue Application of the Biocomposite Materials on Bone Reconstruction)
This study investigated the surface properties and biomechanical behaviors of a nanostructured titanium oxide (TiO) layer with different self-assembled monolayers (SAMs) of phosphonate on the surface of microscope slides. The surface properties of SAMs were analyzed using scanning electron microscopy, X-ray photoemission spectroscopy, and contact angle goniometry. Biomechanical behaviors were evaluated using nanoindentation with a diamond Berkovich indenter. Analytical results indicated that the homogenous nanostructured TiO surface was formed on the substrate surface after the plasma oxidation treatment. As the TiO surface was immersed with 11-phosphonoundecanoic acid solution (PUA-SAM/TiO), the formation of a uniform SAM can be observed on the sample surface. Moreover, the binding energy of O 1s demonstrated the presence of the bisphosphonate monolayer on the SAMs-coated samples. It was also found that the PUA-SAM/TiO sample not only possessed a higher wettability performance, but also exhibited low surface contact stiffness. A SAM surface with a high wettability and low contact stiffness could potentially promote biocompatibility and prevent the formation of a stress shielding effect. Therefore, the self-assembled technology is a promising approach that can be applied to the surface modification of biomedical implants for facilitating bone healing and osseointegration. View Full-Text
Keywords: titanium oxide; self-assembled monolayer; wettability; nanoindentation titanium oxide; self-assembled monolayer; wettability; nanoindentation
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MDPI and ACS Style

Lan, W.-C.; Huang, T.-S.; Cho, Y.-C.; Huang, Y.-T.; Walinski, C.J.; Chiang, P.-C.; Rusilin, M.; Pai, F.-T.; Huang, C.-C.; Huang, M.-S. The Potential of a Nanostructured Titanium Oxide Layer with Self-Assembled Monolayers for Biomedical Applications: Surface Properties and Biomechanical Behaviors. Appl. Sci. 2020, 10, 590.

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