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Open AccessArticle

Experimental Study of Electrical Properties of Pharmaceutical Materials by Electrical Impedance Spectroscopy

1
Tecnológico Nacional de México/Instituto Tecnológico de Morelia, División de Estudios de Posgrado E Investigación, Avenida Tecnológico 1500, Morelia C. P 58120, Michoacán, Mexico
2
Department of Electrical and Electronic Engineering, The University of Manchester, Manchester M13 9PL, UK
3
CINVESTAV/IPN, Av. Instituto Politécnico Nacional 2508, Col. San Pedro Zacatenco, México C.P 07360, D. F., Mexico
*
Author to whom correspondence should be addressed.
Appl. Sci. 2020, 10(18), 6576; https://doi.org/10.3390/app10186576
Received: 10 July 2020 / Revised: 14 September 2020 / Accepted: 15 September 2020 / Published: 21 September 2020
The physicochemical characterization of pharmaceutical materials is essential for drug discovery, development and evaluation, and for understanding and predicting their interaction with physiological systems. Amongst many measurement techniques for spectroscopic characterization of pharmaceutical materials, Electrical Impedance Spectroscopy (EIS) is powerful as it can be used to model the electrical properties of pure substances and compounds in correlation with specific chemical composition. In particular, the accurate measurement of specific properties of drugs is important for evaluating physiological interaction. The electrochemical modelling of compounds is usually carried out using spectral impedance data over a wide frequency range, to fit a predetermined model of an equivalent electrochemical cell. This paper presents experimental results by EIS analysis of four drug formulations (trimethoprim/sulfamethoxazole C14H18N4O3-C10H11N3O3, ambroxol C13H18Br2N2O.HCl, metamizole sodium C13H16N3NaO4S, and ranitidine C13H22N4O3S.HCl). A wide frequency range from 20 Hz to 30 MHz is used to evaluate system identification techniques using EIS data and to obtain process models. The results suggest that arrays of linear R-C models derived using system identification techniques in the frequency domain can be used to identify different compounds. View Full-Text
Keywords: drug modelling; frequency response; electrical impedance spectroscopy; system identification drug modelling; frequency response; electrical impedance spectroscopy; system identification
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MDPI and ACS Style

Vázquez-Nambo, M.; Gutiérrez-Gnecchi, J.-A.; Reyes-Archundia, E.; Yang, W.; Rodriguez-Frias, M.-A.; Olivares-Rojas, J.-C.; Lorias-Espinoza, D. Experimental Study of Electrical Properties of Pharmaceutical Materials by Electrical Impedance Spectroscopy. Appl. Sci. 2020, 10, 6576. https://doi.org/10.3390/app10186576

AMA Style

Vázquez-Nambo M, Gutiérrez-Gnecchi J-A, Reyes-Archundia E, Yang W, Rodriguez-Frias M-A, Olivares-Rojas J-C, Lorias-Espinoza D. Experimental Study of Electrical Properties of Pharmaceutical Materials by Electrical Impedance Spectroscopy. Applied Sciences. 2020; 10(18):6576. https://doi.org/10.3390/app10186576

Chicago/Turabian Style

Vázquez-Nambo, Manuel; Gutiérrez-Gnecchi, José-Antonio; Reyes-Archundia, Enrique; Yang, Wuqiang; Rodriguez-Frias, Marco-A.; Olivares-Rojas, Juan-Carlos; Lorias-Espinoza, Daniel. 2020. "Experimental Study of Electrical Properties of Pharmaceutical Materials by Electrical Impedance Spectroscopy" Appl. Sci. 10, no. 18: 6576. https://doi.org/10.3390/app10186576

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