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Open AccessArticle

An Impedance Sensor in Detection of Immunoglobulin G with Interdigitated Electrodes on Flexible Substrate

1
International Joint Research Center for Nanophotonics and Biophotonics, School of Science, Changchun University of Science and Technology, Changchun 130022, China
2
CAS Key Laboratory of Bio-medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, No. 88 Keling Road, Suzhou 215163, China
*
Author to whom correspondence should be addressed.
Appl. Sci. 2020, 10(11), 4012; https://doi.org/10.3390/app10114012
Received: 26 April 2020 / Revised: 29 May 2020 / Accepted: 3 June 2020 / Published: 10 June 2020
Immunoassay plays an important role in the early screening and diagnosis of diseases. The use of electrochemical methods to realize the label-free, specific and rapid detection of antigens has attracted extensive attention from researchers. In this study, we realized the function of immunosensing and detection by lithography, the interdigitated gold electrode on the polyethylene naphthalate (PEN) membrane. Then, the gold electrode was biofunctionalized and the characterization was verified by atomic force microscopy, which was finally for the detection of mice IgG. This immunosensor has a low detection limit, with a broad linear detection range of 0.01–10 ng/mL. The results show that the electrochemical impedance sensor made of metal electrodes based on PEN flexible materials is suitable for immunoassay experiments. If this method could be proved by further studies, broad application prospects can be seen in routine immunoassays. View Full-Text
Keywords: electrochemical impedance spectroscopy (EIS); immunosensor; flexible electrodes electrochemical impedance spectroscopy (EIS); immunosensor; flexible electrodes
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MDPI and ACS Style

Jin, K.; Zhao, P.; Fang, W.; Zhai, Y.; Hu, S.; Ma, H.; Li, J. An Impedance Sensor in Detection of Immunoglobulin G with Interdigitated Electrodes on Flexible Substrate. Appl. Sci. 2020, 10, 4012.

AMA Style

Jin K, Zhao P, Fang W, Zhai Y, Hu S, Ma H, Li J. An Impedance Sensor in Detection of Immunoglobulin G with Interdigitated Electrodes on Flexible Substrate. Applied Sciences. 2020; 10(11):4012.

Chicago/Turabian Style

Jin, Kai; Zhao, Ping; Fang, Wenhui; Zhai, Yingjiao; Hu, Siyi; Ma, Hanbin; Li, Jinhua. 2020. "An Impedance Sensor in Detection of Immunoglobulin G with Interdigitated Electrodes on Flexible Substrate" Appl. Sci. 10, no. 11: 4012.

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