Climate, Pollution, and Maternal Health: Investigating the Impact of Temperature and Ozone on Birth Outcomes in Phoenix, Arizona
Abstract
:1. Introduction
2. Materials and Methods
Statistical Analysis
3. Results
3.1. Examining Threshold Effects of Ozone and Temperature
3.2. Temperature and Ozone as Mediators or Moderators
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Variables | Value |
---|---|
N = 9499 | |
Maternal Age, years (mean, SD) | 32.3 (6.07) |
Newborn Gender * (n, %) | |
Female | 4566 (49.8) |
Male | 4608 (50.2) |
Race (n, %) | |
White | 2692 (28.3) |
Black or African American | 1037 (10.9) |
Hispanic | 5157 (54.3) |
Asian, NH, or Other PI | 306 (3.22) |
AI/AN | 180 (1.89) |
Multiracial or Unknown | 127 (1.34) |
Obesity (n, %) | |
No | 7404 (77.9) |
Yes | 2095 (22.1) |
Median Household Income(mean, SD) | 54,354.06 (19,118.89) |
Child Gestational Age (mean, SD) | 270.5 (17.0) |
Temperature, (F) * (mean, SD) | 75.8 (13.6) |
Ozone, (ppm) * (mean, SD) | 0.0319 (0.008) |
Variables | Univariate | Multivariable with Temperature | Multivariable with Ozone | |||
---|---|---|---|---|---|---|
Beta (95% CI) | p-value | Beta (95% CI) | p-value | Beta (95% CI) | p-value | |
Ozone (per 0.01 ppm increase) | −17.5 (−31.9, −3.02) | 0.018 | --- | −18.7(−30.5, −6.87) | 0.002 | |
Temperature | −0.59 (−1.45, 0.27) | 0.18 | −0.98 (−1.68, −0.28) | 0.006 | --- | |
Age | 2.61 (0.67, 4.54) | 0.008 | 5.22 (3.61, 6.83) | <0.001 | 5.20 (3.59, 6.82) | <0.001 |
Gender | ||||||
Female | REF | REF | REF | |||
Male | 93.2 (69.5, 116.9) | <0.001 | 111.6 (92.6, 130.6) | <0.001 | 111.0 (91.9, 130.1) | <0.001 |
Race | ||||||
White | REF | REF | REF | |||
Black or African American | −128.1 (−169.7, −86.4) | <0.001 | −118.5 (−152.7, −84.2) | <0.001 | −119.1 (−153.5, −84.8) | <0.001 |
Hispanic | 10.8 (−16.3, 37.9) | 0.43 | 0.29 (−23.0, 23.6) | 0.98 | −0.76 (−24.2, 22.6) | 0.95 |
Asian, NH, or Other PI | −136.5 (−205.2, −67.7) | <0.001 | −107.8 (−163.5, −52.3) | <0.001 | −108.7 (−164.4, −53.1) | <0.001 |
AI/AN | 63.8 (−23.9, 151.6) | 0.15 | 69.1 (−4.09, 142.4) | 0.064 | 65.2 (−8.14, 138.6) | 0.081 |
Multiracial or Unknown | 0.41 | 0.32 | 0.31 | |||
Obesity | ||||||
No | REF | REF | REF | |||
Yes | 128.8 (92.8, 149.0) | <0.001 | 131.8 (108.6, 154.9) | <0.001 | 132.2 (108.9, 155.4) | <0.001 |
Median Household Income (per $10,000 increase) | −0.28 (−0.89, 0.33) | 0.37 | −0.16 (−0.69, 0.36) | 0.54 | −0.068 (−5.96, 4.59) | 0.80 |
Child Gestational Age | 19.8 (19.2, 20.4) | <0.001 | 20.7 (20.1, 21.2) | <0.001 | 20.6 (20.1, 21.2) | <0.001 |
Child Birth Weight as Outcome | Quintiles of Temperature | |||||
---|---|---|---|---|---|---|
Quintile 1 (<60) | Quintile 2 (60.03–67.67) | Quintile 3 (68.16–80.23) | Quintile 4 (80.89–88.13) | Quintile 5 (> 90) | ||
Birthweight Mean (SD) | 3262.7 (591.8) | 3262.0 (582.4) | 3254.4 (584.2) | 3240.1 (577.9) | 3248.2 (564.2) | PTrend |
Models | ||||||
Initial Model a | REF | −0.69 (−39.3, 37.9) | −8.33 (−44.6, 27.9) | −22.6 (−60.4, 15.3) | −14.5 (−51.0, 21.9) | 0.24 |
Full Model b | REF | 4.13 (−27.1, 35.4) | −16.9 (−46.3, 12.5) | −23.9 (−54.5, 6.72) | −30.2 (−59.7, −0.59) * | 0.011 |
Child Birth weight as Outcome | Quintiles of Ozone | |||||
Quintile 1 (<0.02394) | Quintile 2 (0.02397–0.03026) | Quintile 3 (0.03026–0.03576) | Quintile 4 (0.03577–0.03928) | Quintile 5 (>0.03928) | ||
PTrend | ||||||
Birthweight Mean (SD) | 3279.2 (574.9) | 3256.9 (609.9) | 3257.0 (560.4) | 3239.9 (567.9) | 3234.4 (585.8) | |
Models | ||||||
Initial Model a | REF | −22.3 (−59.5, 14.9) | −22.2 (−59.4, 15.0) | −39.4 (−76.5, −2.13) * | −44.8 (−82.0, −7.66) * | 0.012 |
Full Model b | REF | 10.0 (−20.3, 40.3) | −13.4 (−43.7, 16.7) | −29.4 (−59.6, 0.77) | −35.7 (−65.9, −5.31) * | 0.001 |
Variables | Birth Weight as Dependent Variable 1 | Temperature as Dependent Variable 2 | Ozone as Dependent Variable 3 | |||
---|---|---|---|---|---|---|
Beta (95% CI) | p-value | Beta (95% CI) | p-value | Beta (95% CI) | p-value | |
Ozone (per 0.01 ppm increase) | −14.1 (−27.6, −0.69) | 0.039 | 8.09 (7.79, 8.40) * | <0.001 | --- | |
Temperature | −0.56 (−1.35, 0.24) | 0.17 | --- | 0.0002 (0.0002, 0.0003) | <0.001 | |
Age | 5.20 (3.58, 6.81) | <0.001 | −0.005 (−0.05, 0.04) | 0.83 | −0.00002 (−4.76 × , 2.02 ×) | 0.072 |
Gender | 0.95 | |||||
Female | REF | REF | REF | |||
Male | 111.0 (37.9, 130.1) | <0.001 | 0.015 (−0.48, 0.51) | 0.00007 (−0.0002, 0.0004) | 0.63 | |
Race | ||||||
White | REF | REF | REF | |||
Black or African American | −119.0 (−153.4, −84.7) | <0.001 | 0.20 (−0.68, 1.09) | 0.65 | −0.0007 (−0.001, −0.0002) | 0.011 |
Hispanic | −0.53 (−23.9, 22.9) | 0.96 | 0.43 (−0.18, 1.04) | 0.17 | −0.0007 (−0.001, −0.0003) | <0.001 |
Asian, NH, or Other PI | −108.4 (−164.0, −52.7) | <0.001 | 0.68 (−0.76, 2.13) | 0.35 | −0.0003 (−0.001, 0.0006) | 0.56 |
AI/AN | 65.9 (−7.41, 139.3) | 0.078 | 1.33 (−0.57, 3.23) | 0.17 | −0.002 (−0.003, −0.001) | <0.001 |
Multiracial or Unknown | −43.9 (−128.9, 40.9) | 0.31 | 0.49 (−1.70, 2.69) | 0.66 | −0.001 (−0.003, −0.00007) | 0.038 |
Obesity | ||||||
No | REF | REF | REF | |||
Yes | 132.4 (109.1, 155.6) | <0.001 | 0.37 (−0.24, 0.97) | 0.23 | 0.0003 (−9.2 × , 0.0006) | 0.14 |
Median Household Income (per $10,000 increase) | −0.87 (−6.16, 4.41) | 0.75 | −0.34 (−0.48, −0.21) | 4.06 × (3.26 ×, 4.87 ×) | <0.001 | |
Child Gestational Age | 20.6 (20.1, 21.2) | <0.001 | 0.004 (−0.01, 0.02) | 0.57 | −2.09 ×, 0.0006) (−1.10 ×, 6.81 × ) | 0.64 |
Avg Mediation Effect (95% CI) | ||||||
Ozone | −0.41 (−0.79, −0.04) | 0.034 | ||||
Temperature | −0.046 (−0.001, 141.8) | 0.14 | ||||
Proportion-Med (95% CI) | ||||||
Ozone | 0.42 (0.031, 1.67) | 0.042 | ||||
Temperature | 0.24 (0.068, 1.03) | 0.14 |
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Share and Cite
Witsoe, M.; Mickelson, K.; Kang, P.; Dinh, S.; Krzyzanowski, B.; Doddamreddy, S.A.; Doehrman, P.; Zhou, G.; Nguyen, J. Climate, Pollution, and Maternal Health: Investigating the Impact of Temperature and Ozone on Birth Outcomes in Phoenix, Arizona. Environments 2025, 12, 118. https://doi.org/10.3390/environments12040118
Witsoe M, Mickelson K, Kang P, Dinh S, Krzyzanowski B, Doddamreddy SA, Doehrman P, Zhou G, Nguyen J. Climate, Pollution, and Maternal Health: Investigating the Impact of Temperature and Ozone on Birth Outcomes in Phoenix, Arizona. Environments. 2025; 12(4):118. https://doi.org/10.3390/environments12040118
Chicago/Turabian StyleWitsoe, Megan, Kristin Mickelson, Paul Kang, Samantha Dinh, Brittany Krzyzanowski, Sai Anmisha Doddamreddy, Pooja Doehrman, Guangying Zhou, and Jacqueline Nguyen. 2025. "Climate, Pollution, and Maternal Health: Investigating the Impact of Temperature and Ozone on Birth Outcomes in Phoenix, Arizona" Environments 12, no. 4: 118. https://doi.org/10.3390/environments12040118
APA StyleWitsoe, M., Mickelson, K., Kang, P., Dinh, S., Krzyzanowski, B., Doddamreddy, S. A., Doehrman, P., Zhou, G., & Nguyen, J. (2025). Climate, Pollution, and Maternal Health: Investigating the Impact of Temperature and Ozone on Birth Outcomes in Phoenix, Arizona. Environments, 12(4), 118. https://doi.org/10.3390/environments12040118