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Open AccessArticle

Electroacupuncture Reduces Seizure Activity and Enhances GAD 67 and Glutamate Transporter Expression in Kainic Acid Induced Status Epilepticus in Infant Rats

1
Unidad de Investigación Médica en Enfermedades Neurológicas, Hospital de Especialidades “Dr. Bernardo Sepúlveda”, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), Ciudad de México CP.06720, Mexico
2
Laboratorio de Nanomateriales, Centro de Investigación en Ciencias de la Salud, Universidad Autónoma de San Luis Potosí, Estado de San Luis Potosí CP.78210, Mexico
3
Unidad de Investigación en Farmacología, Hospital de Especialidades, “Dr. Bernardo Sepúlveda”, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), Ciudad de México CP.06720, Mexico
*
Author to whom correspondence should be addressed.
Behav. Sci. 2019, 9(7), 68; https://doi.org/10.3390/bs9070068
Received: 11 April 2019 / Revised: 10 June 2019 / Accepted: 21 June 2019 / Published: 27 June 2019
(This article belongs to the Special Issue From Basic to Clinical in Behavioral Disorders)
Status epilepticus (SE) is one of the most significant complications in pediatric neurology. Clinical studies have shown positive effects of electroacupuncture (EA) as a therapeutic alternative in the control of partial seizures and secondary generalized clonic seizures. EA promotes the release of neurotransmitters such as GABA and some opioids. The present study aimed to evaluate the anticonvulsive and neuromodulatory effects of Shui Gou DM26 (SG_DM26) acupuncture point electrostimulation on the expression of the glutamate decarboxylase 67 (GAD67) enzyme and the glutamate transporter EAAC1 in an early SE model. At ten postnatal days (10-PD), male rats weighing 22–26 g were divided into 16 groups, including control and treatment groups: Simple stimulation, electrostimulation, anticonvulsant drug treatment, and combined treatment—electrostimulation and pentobarbital (PB). SE was induced with kainic acid (KA), and the following parameters were measured: Motor behavior, and expression of GAD67 and EAAC1. The results suggest an antiepileptic effect derived from SG DM26 point EA. The possible mechanism is most likely the increased production of the inhibitory neurotransmitter GABA, which is observed as an increase in the expression of both GAD67 and EAAC1, as well as the potential synergy between the neuromodulator effects of EA and PB. View Full-Text
Keywords: electroacupuncture; kainic acid; Status epilepticus; GAD67; EAAC1 electroacupuncture; kainic acid; Status epilepticus; GAD67; EAAC1
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Vega-García, A.; Neri-Gómez, T.; Buzoianu-Anguiano, V.; Guerra-Araiza, C.; Segura-Uribe, J.; Feria-Romero, I.; Orozco-Suarez, S. Electroacupuncture Reduces Seizure Activity and Enhances GAD 67 and Glutamate Transporter Expression in Kainic Acid Induced Status Epilepticus in Infant Rats. Behav. Sci. 2019, 9, 68.

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