Complete Blood Count-Derived Inflammatory Markers Changes in Dogs with Chronic Inflammatory Enteropathy Treated with Adipose-Derived Mesenchymal Stem Cells
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Animals
2.2. Isolation and In Vitro Expansion of Adipose-Derived Mesenchymal Stem Cells (Ad-MSCs)
2.3. Study Protocol
2.4. Statistical Study
3. Results
3.1. Population
3.2. Clinical Indices
3.3. Changes in the Neutrophil, Lymphocyte, and Platelet Counts
3.4. Blood Inflammatory Indices
3.5. Association between Inflammatory Indices and the Parameters Analyzed
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Reference Value | T0 | T2 | T9 | p | |
---|---|---|---|---|---|
CCECAI | 8.5 (1–14) a | 1.75 (0–6) b | 1 (0–4) c | <0.0001 | |
Effect size (95% CI) | - | 2.83 (1.79; 3.73) | 3.42 (2.26; 4.40) | ||
Neutrophils (×103/µL) | 5.78 (2.65–10.24) | 7.8 (3–16.9) a | 6.25 (3.53–7.9) b | 5.88 (4.26–7.12) b | 0.003 |
Effect size (95% CI) | 0.85 (0.11; 1.55) | 0.96 (0.21; 1.67) | |||
Lymphocytes (×103/µL) | 3.05 (1.40–5.52) | 1.49 (0.95–3.18) a | 2 (0.96–4.83) a | 2.38 (1.46–3.71) b | 0.039 |
Effect size (95% CI) | −0.76 (−1.46; −0.03) | −1.25 (−1.97; −0.46) | |||
Platelets (×103/µL) | 141 (67–501) | 243.5 (119–611) a | 221 (116–324) a | 214 (112–341) b | 0.019 |
Effect size (95% CI) | 0.60 (−0.12; 1.29) | 0.76 (0.02; 1.46) | |||
NLR | 2.11 (0.74–5.62) | 4.58 (1.62–17.24) a | 3.24 (1.68–5.76) b | 2.35 (1.47–4.39) c | 0.002 |
Effect size (95% CI) | 0.96 (0.20; 1.66) | 1.21 (0.43; 1.93) | |||
PLR | 56.41 (15.34–198.02) | 181.42 (102.35–364.29) a | 107.54 (45.53–179.73) b | 89.37 (50.80–145.40) c | |
Effect size (95% CI) | 1.28 (0.49; 2.01) | 1.72 (0.87; 2.48) | |||
SII (×103) | 360.98 (52.93–1503) | 1071.76 (475.94–6156.43) a | 662.13 (273.18–1227.55) b | 547.66 (308.08–878.23) c | |
Effect size (95% CI) | 0.99 (0.23; 1.69) | 1.16 (0.39; 1.88) |
NLR | PLR | SII | ||||
---|---|---|---|---|---|---|
Spearman ρ | p Value | Spearman ρ | p Value | Spearman ρ | p Value | |
Neutrophils | 0.71 | <0.0001 | 0.38 | 0.01 | 0.73 | <0.0001 |
Lymphocytes | −0.82 | <0.0001 | −0.67 | <0.0001 | −0.59 | <0.0001 |
Platelets | 0.003 | 0.99 | 0.54 | <0.0001 | 0.54 | <0.0001 |
NLR | - | - | 0.62 | <0.0001 | 0.77 | <0.0001 |
PLR | 0.63 | <0.0001 | - | - | 0.87 | <0.0001 |
SII | 0.77 | <0.0001 | 0.87 | <0.0001 | - | - |
CCECAI | 0.52 | <0.0001 | 0.53 | <0.0001 | 0.495 | <0.0001 |
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Cristóbal, J.I.; Duque, F.J.; Usón-Casaús, J.; Barrera, R.; López, E.; Pérez-Merino, E.M. Complete Blood Count-Derived Inflammatory Markers Changes in Dogs with Chronic Inflammatory Enteropathy Treated with Adipose-Derived Mesenchymal Stem Cells. Animals 2022, 12, 2798. https://doi.org/10.3390/ani12202798
Cristóbal JI, Duque FJ, Usón-Casaús J, Barrera R, López E, Pérez-Merino EM. Complete Blood Count-Derived Inflammatory Markers Changes in Dogs with Chronic Inflammatory Enteropathy Treated with Adipose-Derived Mesenchymal Stem Cells. Animals. 2022; 12(20):2798. https://doi.org/10.3390/ani12202798
Chicago/Turabian StyleCristóbal, José Ignacio, Francisco Javier Duque, Jesús Usón-Casaús, Rafael Barrera, Esther López, and Eva María Pérez-Merino. 2022. "Complete Blood Count-Derived Inflammatory Markers Changes in Dogs with Chronic Inflammatory Enteropathy Treated with Adipose-Derived Mesenchymal Stem Cells" Animals 12, no. 20: 2798. https://doi.org/10.3390/ani12202798
APA StyleCristóbal, J. I., Duque, F. J., Usón-Casaús, J., Barrera, R., López, E., & Pérez-Merino, E. M. (2022). Complete Blood Count-Derived Inflammatory Markers Changes in Dogs with Chronic Inflammatory Enteropathy Treated with Adipose-Derived Mesenchymal Stem Cells. Animals, 12(20), 2798. https://doi.org/10.3390/ani12202798