Next Article in Journal
Context-Dependent Gestural Laterality: A Multifactorial Analysis in Captive Red-Capped Mangabeys
Next Article in Special Issue
Identification of Candidate Genes for Pigmentation in Camels Using Genotyping-by-Sequencing
Previous Article in Journal
Influence of Broiler Age on the Apparent Metabolizable Energy of Cereal Grains Determined Using the Substitution Method
Previous Article in Special Issue
First Report of Antimicrobial Susceptibility and Virulence Gene Characterization Associated with Staphylococcus aureus Carriage in Healthy Camels from Tunisia
Article

Gene-Set Enrichment Analysis for Identifying Genes and Biological Activities Associated with Growth Traits in Dromedaries

1
Animal Science Research Department, Yazd Agricultural and Natural Resources Research and Education Center, Agricultural Research, Education & Extension Organization (AREEO), Yazd 8915813155, Iran
2
Department of Animal Science, Faculty of Agriculture, University of Jiroft, Jiroft 7867155311, Iran
3
Department of Animal Viral Diseases Research, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization, Karaj 3146618361, Iran
4
Animal Science Research Institute of Iran, Agricultural Research, Education and Extension Organization (AREEO), Karaj 3146618361, Iran
5
Department of Animal Breeding and Genetics (HGEN), Centre for Veterinary Medicine and Animal Science (VHC), Swedish University of Agricultural Sciences (SLU), 75007 Uppsala, Sweden
6
Research Institute of Wildlife Ecology, Vetmeduni Vienna, 1160 Vienna, Austria
*
Author to whom correspondence should be addressed.
Academic Editors: Michela Pugliese, Annamaria Passantino, Asim Faraz and Maria Luisa Dettori
Animals 2022, 12(2), 184; https://doi.org/10.3390/ani12020184
Received: 15 December 2021 / Revised: 9 January 2022 / Accepted: 11 January 2022 / Published: 13 January 2022
(This article belongs to the Special Issue Trends in Camel Health and Production)
This project aimed to find biological themes affecting growth in dromedaries. Candidate SNPs associated with growth were mapped to 22 genes, and 25 significant themes were identified related to growth. The main biological functions included calcium ion binding, protein binding, DNA-binding transcription factor activity, protein kinase activity, tropomyosin binding, myosin complex, actin-binding, ATP binding, receptor signaling pathway via JAK-STAT, and cytokine activity. EFCAB5, MTIF2, MYO3A, TBX15, IFNL3, PREX1, and TMOD3 genes are candidates for improving growth in camel breeding programs.
Growth is an important heritable economic trait for dromedaries and necessary for planning a successful breeding program. Until now, genome-wide association studies (GWAS) and QTL-mapping have identified significant single nucleotide polymorphisms (SNPs) associated with growth in domestic animals, but in dromedaries, the number of studies is very low. This project aimed to find biological themes affecting growth in dromedaries. In the first step, 99 candidate SNPs were chosen from a previously established set of SNPs associated with body weight, gain, and birth weight in Iranian dromedaries. Next, 0.5 kb upstream and downstream of each candidate SNP were selected from NCBI (assembly accession: GCA_000803125.3). The annotation of fragments with candidate SNPs regarding the reference genome was retrieved using the Blast2GO tool. Candidate SNPs associated with growth were mapped to 22 genes, and 25 significant biological themes were identified to be related to growth in dromedaries. The main biological functions included calcium ion binding, protein binding, DNA-binding transcription factor activity, protein kinase activity, tropomyosin binding, myosin complex, actin-binding, ATP binding, receptor signaling pathway via JAK-STAT, and cytokine activity. EFCAB5, MTIF2, MYO3A, TBX15, IFNL3, PREX1, and TMOD3 genes are candidates for improving growth in camel breeding programs. View Full-Text
Keywords: growth; biological theme; gene ontology; dromedaries growth; biological theme; gene ontology; dromedaries
Show Figures

Figure 1

MDPI and ACS Style

Sani, M.B.; Roudbari, Z.; Karimi, O.; Banabazi, M.H.; Esmaeilkhanian, S.; Asadzadeh, N.; Zare Harofte, J.; Shafei Naderi, A.; Burger, P.A. Gene-Set Enrichment Analysis for Identifying Genes and Biological Activities Associated with Growth Traits in Dromedaries. Animals 2022, 12, 184. https://doi.org/10.3390/ani12020184

AMA Style

Sani MB, Roudbari Z, Karimi O, Banabazi MH, Esmaeilkhanian S, Asadzadeh N, Zare Harofte J, Shafei Naderi A, Burger PA. Gene-Set Enrichment Analysis for Identifying Genes and Biological Activities Associated with Growth Traits in Dromedaries. Animals. 2022; 12(2):184. https://doi.org/10.3390/ani12020184

Chicago/Turabian Style

Sani, Morteza B., Zahra Roudbari, Omid Karimi, Mohammad H. Banabazi, Saeid Esmaeilkhanian, Nader Asadzadeh, Javad Zare Harofte, Ali Shafei Naderi, and Pamela A. Burger. 2022. "Gene-Set Enrichment Analysis for Identifying Genes and Biological Activities Associated with Growth Traits in Dromedaries" Animals 12, no. 2: 184. https://doi.org/10.3390/ani12020184

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop