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Article

Spatial and Temporal Distribution of Mycobacterium tuberculosis Complex Infection in Eurasian Badger (Meles meles) and Cattle in Asturias, Spain

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Servicio Regional de Investigación y Desarrollo Agroalimentario del Principado de Asturias (SERIDA), 33300 Villaviciosa, Spain
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Laboratório de Imunologia e Biologia Molecular, Instituto de Ciências da Saúde, Universidade Federal da Bahia, 40.110-100 Salvador, Bahia, Brazil
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Centro de Vigilancia Sanitaria Veterinaria VISAVET, Universidad Complutense, 28040 Madrid, Spain
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Servicio de Sanidad y Producción Animal del Principado de Asturias, 33007 Oviedo, Asturias, Spain
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Laboratorio Regional de Sanidad Animal del Principado de Asturias, 33201 Gijón, Asturias, Spain
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Dirección General del Medio Natural y Planificación Rural del Principado de Asturias, 33007 Oviedo, Asturias, Spain
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Animal Health Department, NEIKER-Instituto Vasco de Investigación y Desarrollo Agrario, 48160 Derio, Bizkaia, Spain
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Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad Complutense, 28040 Madrid, Spain
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Unidad de Inmunología Microbiana, Centro Nacional de Microbiología, Instituto de Salud Carlos III, 28029 Madrid, Spain
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Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad de León, 24071 León, Spain
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Departamento de Sanidad Animal, Instituto de Ganadería de Montaña (CSIC-Universidad de León), Finca Marzanas, Grulleros, 24346 León, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Nicole Gottdenker
Animals 2021, 11(5), 1294; https://doi.org/10.3390/ani11051294
Received: 1 March 2021 / Revised: 26 April 2021 / Accepted: 28 April 2021 / Published: 30 April 2021
(This article belongs to the Special Issue Zoonoses and Wildlife: One Health Approach)
The aim of the present work was to investigate the prevalence, spatial distribution, and temporal distribution of tuberculosis in 673 free-ranging Eurasian badgers (Meles meles) and cattle from Asturias (Atlantic Spain) during a 13-year follow-up. The study objective was to assess the role of badgers as a reservoir of tuberculosis for cattle and other sympatric wild species in the region. During the follow-up, 27/639 badgers (4.23%) were positive for the Mycobacterium tuberculosis complex based on bacterial isolation, while 160/673 (23.77%) were positive based on P22 ELISA. Badger infection was spatially and temporally associated with cattle herd infection.
The present work investigated the prevalence, spatial distribution, and temporal distribution of tuberculosis (TB) in free-ranging Eurasian badgers (Meles meles) and cattle in Asturias (Atlantic Spain) during a 13-year follow-up. The study objective was to assess the role of badgers as a TB reservoir for cattle and other sympatric wild species in the region. Between 2008 and 2020, 673 badgers (98 trapped and 575 killed in road traffic accidents) in Asturias were necropsied, and their tissue samples were cultured for the Mycobacterium tuberculosis complex (MTC) isolation. Serum samples were tested in an in-house indirect P22 ELISA to detect antibodies against the MTC. In parallel, data on MTC isolation and single intradermal tuberculin test results were extracted for cattle that were tested and culled as part of the Spanish National Program for the Eradication of Bovine TB. A total of 27/639 badgers (4.23%) were positive for MTC based on bacterial isolation, while 160/673 badgers (23.77%) were found to be positive with the P22 ELISA. The rate of seropositivity was higher among adult badgers than subadults. Badger TB status was spatially and temporally associated with cattle TB status. Our results cannot determine the direction of possible interspecies transmission, but they are consistent with the idea that the two hosts may exert infection pressure on each other. This study highlights the importance of the wildlife monitoring of infection and disease during epidemiological interventions in order to optimize outcomes. View Full-Text
Keywords: Meles meles; badger; tuberculosis; Mycobacterium tuberculosis complex; P22 ELISA; isolation; serology; cattle; Atlantic Spain Meles meles; badger; tuberculosis; Mycobacterium tuberculosis complex; P22 ELISA; isolation; serology; cattle; Atlantic Spain
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MDPI and ACS Style

Blanco Vázquez, C.; Barral, T.D.; Romero, B.; Queipo, M.; Merediz, I.; Quirós, P.; Armenteros, J.Á.; Juste, R.; Domínguez, L.; Domínguez, M.; Casais, R.; Balseiro, A. Spatial and Temporal Distribution of Mycobacterium tuberculosis Complex Infection in Eurasian Badger (Meles meles) and Cattle in Asturias, Spain. Animals 2021, 11, 1294. https://doi.org/10.3390/ani11051294

AMA Style

Blanco Vázquez C, Barral TD, Romero B, Queipo M, Merediz I, Quirós P, Armenteros JÁ, Juste R, Domínguez L, Domínguez M, Casais R, Balseiro A. Spatial and Temporal Distribution of Mycobacterium tuberculosis Complex Infection in Eurasian Badger (Meles meles) and Cattle in Asturias, Spain. Animals. 2021; 11(5):1294. https://doi.org/10.3390/ani11051294

Chicago/Turabian Style

Blanco Vázquez, Cristina, Thiago D. Barral, Beatriz Romero, Manuel Queipo, Isabel Merediz, Pablo Quirós, José Á. Armenteros, Ramón Juste, Lucas Domínguez, Mercedes Domínguez, Rosa Casais, and Ana Balseiro. 2021. "Spatial and Temporal Distribution of Mycobacterium tuberculosis Complex Infection in Eurasian Badger (Meles meles) and Cattle in Asturias, Spain" Animals 11, no. 5: 1294. https://doi.org/10.3390/ani11051294

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