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Open AccessArticle

Associations between the Bovine Myostatin Gene and Milk Fatty Acid Composition in New Zealand Holstein-Friesian × Jersey-Cross Cows

Gene-Marker Laboratory, Department of Agricultural Sciences, Faculty of Agriculture and Life Sciences, Lincoln University, Lincoln 7647, New Zealand
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Animals 2020, 10(9), 1447; https://doi.org/10.3390/ani10091447
Received: 26 May 2020 / Revised: 11 August 2020 / Accepted: 15 August 2020 / Published: 19 August 2020
(This article belongs to the Special Issue High-Yielding Dairy Cows)
The gene that encodes myostatin influences more than one trait, and its expression has been observed in skeletal muscle, as well as the mammary gland. In this study, association analysis revealed that variation in the bovine myostatin gene affects milk fatty acid composition, raising the possibility that this genetic variation may be utilized to increase the amount of unsaturated fatty acid and decrease the amount of saturated fatty acid in milk.
The myostatin gene (MSTN), which encodes the protein myostatin, is pleiotropic, and its expression has been associated with both increased and decreased adipogenesis and increased skeletal muscle mass in animals. In this study, the polymerase chain reaction, coupled with single strand conformation polymorphism analysis, was utilized to reveal nucleotide sequence variation in bovine MSTN in 410 New Zealand (NZ) Holstein-Friesian × Jersey (HF × J)-cross cows. These cows ranged from 3 to 9 years of age and over the time studied, produced an average 22.53 ± 2.18 L of milk per day, with an average milk fat content of 4.94 ± 0.17% and average milk protein content of 4.03 ± 0.10%. Analysis of a 406-bp amplicon from the intron 1 region, revealed five nucleotide sequence variants (A–E) that contained seven nucleotide substitutions. Using general linear mixed-effect model analyses the AD genotype was associated with reduced C10:0, C12:0, and C12:1 levels when compared to levels in cows with the AA genotype. These associations in NZ HF × J cross cows are novel, and they suggest that this variation in bovine MSTN could be explored for increasing the amount of milk unsaturated fatty acid and decreasing the amount of saturated fatty acid. View Full-Text
Keywords: myostatin gene; variation; milk; fatty acid; cattle myostatin gene; variation; milk; fatty acid; cattle
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MDPI and ACS Style

Haruna, I.L.; Li, Y.; Ekegbu, U.J.; Amirpour-Najafabadi, H.; Zhou, H.; Hickford, J.G.H. Associations between the Bovine Myostatin Gene and Milk Fatty Acid Composition in New Zealand Holstein-Friesian × Jersey-Cross Cows. Animals 2020, 10, 1447.

AMA Style

Haruna IL, Li Y, Ekegbu UJ, Amirpour-Najafabadi H, Zhou H, Hickford JGH. Associations between the Bovine Myostatin Gene and Milk Fatty Acid Composition in New Zealand Holstein-Friesian × Jersey-Cross Cows. Animals. 2020; 10(9):1447.

Chicago/Turabian Style

Haruna, Ishaku L.; Li, Yunhai; Ekegbu, Ugonna J.; Amirpour-Najafabadi, Hamed; Zhou, Huitong; Hickford, Jon G.H. 2020. "Associations between the Bovine Myostatin Gene and Milk Fatty Acid Composition in New Zealand Holstein-Friesian × Jersey-Cross Cows" Animals 10, no. 9: 1447.

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