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Open AccessArticle

A Novel Therapeutic Reagent, KA-1002 for Alleviating Lysophosphatidic Acid-Mediated Inflammation Related Gene Expression in Swine Macrophages

1
Bio and Drug Discovery Division, Center for Information-Based Drug Research, Research Institute of Chemical Technology (KRICT), Daejeon 34114, Korea
2
Department of Predictive Toxicology, Korea Institute of Toxicology, Daejeon 34114, Korea
3
Department of Human and Environmental Toxicology, University of Science and Technology, Daejeon 34113, Korea
4
Chungnam National University School of Medicine, Daejeon 34137, Korea
5
Department of Biochemistry, College of Natural Sciences, Chungnam National University, Daejeon 34134, Korea
6
Department of Pharmaceutical Science, Kyunghee University, Seoul 02447, Korea
7
College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk 28644, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Animals 2020, 10(3), 534; https://doi.org/10.3390/ani10030534
Received: 2 March 2020 / Revised: 16 March 2020 / Accepted: 18 March 2020 / Published: 23 March 2020
(This article belongs to the Section Animal Physiology)
Inflammatory diseases are a key factor reducing the productivity of animals in a livestock industrial environment. We have identified a novel lysophosphatidic acid signaling antagonist, KA-1002, which alleviates lysophosphatidic acid-mediated a broad range of inflammation related gene expression in swine macrophages. Specifically, we found that KA-1002 significantly alleviated LPA-induced genes related with inflammation such as a role of macrophages, fibroblasts and endothelial cells in rheumatoid arthritis and STAT3 signal pathway. Taken together, KA-1002 could be considered a novel therapeutic reagent candidate for swine inflammatory diseases.
Stresses and various infectious reagents caused multiple inflammatory diseases in swine in a livestock industrial environment. Therefore, there is a need for an effective therapeutic or preventive agent that could alleviate chronic and acute inflammation. We found that lysophosphatidic acid (LPA), a stress-induced potent endogenous inflammatory molecule, causes a broad range-regulation of inflammation related genes inflammation in swine macrophages. We further investigated the genome scaled transcriptional regulatory effect of a novel LPA-signaling antagonist, KA-1002 on swine macrophages, inducing the alleviated LPA-mediated inflammation related gene expression. Therefore, KA-1002 could potentially serve as a novel therapeutic or preventive agent to maintain physiologically healthy and balanced conditions of pigs. View Full-Text
Keywords: swine macrophages; lysophosphatidic acid; antagonist; inflammation; RNA-Seq swine macrophages; lysophosphatidic acid; antagonist; inflammation; RNA-Seq
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MDPI and ACS Style

Hwang, H.-J.; Park, T.; Kim, M.; Shin, H.-S.; Hwang, W.; Min, Y.K.; Song, S.-G.; Park, D.; Lee, C.H. A Novel Therapeutic Reagent, KA-1002 for Alleviating Lysophosphatidic Acid-Mediated Inflammation Related Gene Expression in Swine Macrophages. Animals 2020, 10, 534.

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