In Vitro Efficiency of Antimicrobial Peptides against Staphylococcal Pathogens Associated with Canine Pyoderma
Department of Oral Microbiology, Faculty of Medicine, Medical University of Gdansk, Gdansk, 25 Dębowa Str., 80-204 Gdansk, Poland
Department of Inorganic Chemistry, Faculty of Pharmacy, Medical University of Gdansk, Gdansk, 107 Gen. J. Hallera Str., 80-416 Gdansk, Poland
Author to whom correspondence should be addressed.
Received: 20 February 2020 / Revised: 6 March 2020 / Accepted: 8 March 2020 / Published: 11 March 2020
Coagulase-positive staphylococci (CoPS) are predominant pathogens in canine pyoderma, especially S. pseudintermedius and S. aureus. The antimicrobial resistance of CoPS has a key role in the management of canine skin infections. The vast majority of those diseases have a chronic character with a tendency to recur, which is reflected by recurrent systemic antibiotic therapy, associated with an alarming increase in the proportion of antibiotic-resistant staphylococci. Antimicrobial peptides (AMPs) seem to be a promising alternative to conventional antibiotics. The aim of this in vitro study was to evaluate the antimicrobial activity of selected AMPs against pathogenic staphylococcal strains, including multidrug- and methicillin-resistant strains isolated from canine pyoderma cases. The tested AMPs were shown to be equally efficient antimicrobial agents against resistant- and susceptible pathogenic staphylococcal strains associated with canine pyoderma. AMPs were more efficient against S. pseudintermedius than against S. aureus strains. Our findings seem to be particularly interesting from a clinical perspective, as a starting point from which to perform in vivo experiments to estimate the usefulness of these peptides as topical drug molecules for the treatment of canine pyoderma.