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Article

Post-COVID-19 Syndrome: Nine Months after SARS-CoV-2 Infection in a Cohort of 354 Patients: Data from the First Wave of COVID-19 in Nord Franche-Comté Hospital, France

1
Infectious Disease Department, Nord Franche-Comté Hospital, 90400 Trevenans, France
2
Diabetology and Endocrinology Department, Nord Franche-Comté Hospital, 90400 Trevenans, France
3
Virology Department, University Hospital of Besançon, 25000 Besançon, France
4
Faculty of Medicine of Tunis, University Tunis El Manar, Tunis 1007, Tunisia
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Internal Medicine Department, Groupe Hospitalier Sud Ile de France, 77000 Melun, France
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Microbiology Department, Nord Franche-Comté Hospital, 90400 Trevenans, France
7
Infectious Disease Department, University Hospital of Besançon, 25000 Besançon, France
*
Author to whom correspondence should be addressed.
Academic Editors: Sofia Costa-de-Oliveira and Paolo Calistri
Microorganisms 2021, 9(8), 1719; https://doi.org/10.3390/microorganisms9081719
Received: 29 June 2021 / Accepted: 10 August 2021 / Published: 12 August 2021
(This article belongs to the Special Issue COVID-19: Focusing on Epidemiologic, Virologic, and Clinical Studies)
(1) Background. Post-COVID-19 syndrome is defined as the persistence of symptoms after confirmed SARS-CoV-2 infection. (2) Methods. ANOSVID is an observational retrospective study in Nord Franche-Comté Hospital in France that included adult COVID-19 patients confirmed by RT-PCR from 1 March 2020 to 31 May 2020. The aim was to describe patients with post-COVID-19 syndrome with persistent symptoms (PS group) and to compare them with the patients without persistent symptoms (no-PS group). (3) Results. Of the 354 COVID-19 patients, 35.9% (n = 127) reported persistence of at least one symptom after a mean of 289.1 ± 24.5 days after symptom onset. Moreover, 115 patients reported a recurrence of symptoms after recovery, and only 12 patients reported continuous symptoms. The mean age of patients was 48.6 years (19–93) ± 19.4, and 81 patients (63.8%) were female. Patients in the PS group had a longer duration of symptoms of initial acute SARS-CoV-2 infection than patients in the no-PS group (respectively, 57.1 ± 82.1 days versus 29.7 ± 42.1 days, p < 0.001). A majority of patients (n = 104, 81.9%) reported three or more symptoms. The most prevalent persistent symptoms were loss of smell (74.0%, n = 94), fatigue (53.5%, n = 68), loss of taste (31.5%, n = 40), and dyspnea (30.7%, n = 39). These were followed by pain symptoms (26.8% (n = 34), 26.0% (n = 33), 24.4% (n = 31); headache, arthralgia, and myalgia, respectively). More than half of patients reporting persistent symptoms (58%, n = 73) were healthcare workers (HCWs). Among outpatients, this population was more present in the PS group than the no-PS group ((86.6%) n = 71/82 versus (72.2%) n = 109/151, p = 0.012). Post-COVID-19 syndrome was more frequent in patients with a past history of chronic rhinosinusitis (8.7% (n = 11%) versus 1.3% (n = 3), p < 0.001). No significant difference was found regarding clinical characteristics and outcome, laboratory, imaging findings, and treatment received in the two groups. (4) Conclusions. More than a third of our COVID-19 patients presented persistent symptoms after SARS-CoV-2 infection, particularly through loss of smell, loss of taste, fatigue, and dyspnea, with a high prevalence in HCWs among COVID-19 outpatients. View Full-Text
Keywords: post-COVID-19; long COVID-19; follow-up; fatigue; dyspnea; health care workers post-COVID-19; long COVID-19; follow-up; fatigue; dyspnea; health care workers
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MDPI and ACS Style

Zayet, S.; Zahra, H.; Royer, P.-Y.; Tipirdamaz, C.; Mercier, J.; Gendrin, V.; Lepiller, Q.; Marty-Quinternet, S.; Osman, M.; Belfeki, N.; Toko, L.; Garnier, P.; Pierron, A.; Plantin, J.; Messin, L.; Villemain, M.; Bouiller, K.; Klopfenstein, T. Post-COVID-19 Syndrome: Nine Months after SARS-CoV-2 Infection in a Cohort of 354 Patients: Data from the First Wave of COVID-19 in Nord Franche-Comté Hospital, France. Microorganisms 2021, 9, 1719. https://doi.org/10.3390/microorganisms9081719

AMA Style

Zayet S, Zahra H, Royer P-Y, Tipirdamaz C, Mercier J, Gendrin V, Lepiller Q, Marty-Quinternet S, Osman M, Belfeki N, Toko L, Garnier P, Pierron A, Plantin J, Messin L, Villemain M, Bouiller K, Klopfenstein T. Post-COVID-19 Syndrome: Nine Months after SARS-CoV-2 Infection in a Cohort of 354 Patients: Data from the First Wave of COVID-19 in Nord Franche-Comté Hospital, France. Microorganisms. 2021; 9(8):1719. https://doi.org/10.3390/microorganisms9081719

Chicago/Turabian Style

Zayet, Souheil, Hajer Zahra, Pierre-Yves Royer, Can Tipirdamaz, Julien Mercier, Vincent Gendrin, Quentin Lepiller, Solène Marty-Quinternet, Molka Osman, Nabil Belfeki, Lynda Toko, Pauline Garnier, Alix Pierron, Julie Plantin, Louise Messin, Marc Villemain, Kevin Bouiller, and Timothée Klopfenstein. 2021. "Post-COVID-19 Syndrome: Nine Months after SARS-CoV-2 Infection in a Cohort of 354 Patients: Data from the First Wave of COVID-19 in Nord Franche-Comté Hospital, France" Microorganisms 9, no. 8: 1719. https://doi.org/10.3390/microorganisms9081719

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