Next Article in Journal
Early Post-Prandial Regulation of Protein Expression in the Midgut of Chagas Disease Vector Rhodnius prolixus Highlights New Potential Targets for Vector Control Strategy
Next Article in Special Issue
A Phase II Study on the Use of Convalescent Plasma for the Treatment of Severe COVID-19- A Propensity Score-Matched Control Analysis
Previous Article in Journal
Effect of Lactylate and Bacillus subtilis on Growth Performance, Peripheral Blood Cell Profile, and Gut Microbiota of Nursery Pigs
Previous Article in Special Issue
Persistence of Anti-SARS-CoV-2 Antibodies Depends on the Analytical Kit: A Report for Up to 10 Months after Infection
Article

Implementing SARS-CoV-2 Rapid Antigen Testing in the Emergency Ward of a Swiss University Hospital: The INCREASE Study

1
Institute of Microbiology, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland
2
Service of Hospital Preventive Medicine, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland
3
Service of Infectious Diseases, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland
4
Emergency Department, Lausanne University Hospital, 1011 Lausanne, Switzerland
5
ADMed Microbiologie Laboratory, 2300 La Chaux-de-Fonds, Switzerland
6
Clinical Bacteriology and Mycology, University Hospital Basel, 4001 Basel, Switzerland
7
Applied Microbiology Research, Department of Biomedicine, University of Basel, 4031 Basel, Switzerland
8
Institute of immunology, University Hospital of Lausanne, 1011 Lausanne, Switzerland
*
Author to whom correspondence should be addressed.
Academic Editor: Oliver Schildgen
Microorganisms 2021, 9(4), 798; https://doi.org/10.3390/microorganisms9040798
Received: 12 March 2021 / Revised: 7 April 2021 / Accepted: 8 April 2021 / Published: 10 April 2021
(This article belongs to the Special Issue COVID-19: Focusing on Epidemiologic, Virologic, and Clinical Studies)
Following the Swiss Federal Office of Public Health (FOPH) authorization of the rapid antigen test (RAT), we implemented the use of the RAT in the emergency ward of our university hospital for patients’ cohorting. RAT triaging in association with RT-PCR allowed us to promptly isolate positive patients and save resources. Among 532 patients, overall sensitivities were 48.3% for Exdia and 41.2% for Standard Q®, PanbioTM and BD Veritor™. All RATs exhibited specificity above 99%. Sensitivity increased to 74.6%, 66.2%, 66.2% and 64.8% for Exdia, Standard Q®, PanbioTM and BD Veritor™, respectively, for viral loads above 105 copies/mL, to 100%, 97.8%, 96.6% and 95.6% for viral loads above 106 copies/mL and 100% for viral loads above 107 copies/mL. Sensitivity was significantly higher for patients with symptoms onset within four days (74.3%, 69.2%, 69.2% and 64%, respectively) versus patients with the evolution of symptoms longer than four days (36.8%, 21.1%, 21.1% and 23.7%, respectively). Among COVID-19 asymptomatic patients, sensitivity was 33%. All Immunoglobulin-A-positive patients resulted negative for RAT. The RAT might represent a useful resource in selected clinical settings as a complementary tool in RT-PCR for rapid patient triaging, but the lower sensitivity, especially in late presenters and COVID-19 asymptomatic subjects, must be taken into account. View Full-Text
Keywords: SARS-CoV-2; COVID-19 diagnostic testing; rapid antigen test; health plan implementation; nucleocapsid protein; emergency ward SARS-CoV-2; COVID-19 diagnostic testing; rapid antigen test; health plan implementation; nucleocapsid protein; emergency ward
Show Figures

Figure 1

MDPI and ACS Style

Caruana, G.; Croxatto, A.; Kampouri, E.; Kritikos, A.; Opota, O.; Foerster, M.; Brouillet, R.; Senn, L.; Lienhard, R.; Egli, A.; Pantaleo, G.; Carron, P.-N.; Greub, G. Implementing SARS-CoV-2 Rapid Antigen Testing in the Emergency Ward of a Swiss University Hospital: The INCREASE Study. Microorganisms 2021, 9, 798. https://doi.org/10.3390/microorganisms9040798

AMA Style

Caruana G, Croxatto A, Kampouri E, Kritikos A, Opota O, Foerster M, Brouillet R, Senn L, Lienhard R, Egli A, Pantaleo G, Carron P-N, Greub G. Implementing SARS-CoV-2 Rapid Antigen Testing in the Emergency Ward of a Swiss University Hospital: The INCREASE Study. Microorganisms. 2021; 9(4):798. https://doi.org/10.3390/microorganisms9040798

Chicago/Turabian Style

Caruana, Giorgia, Antony Croxatto, Eleftheria Kampouri, Antonios Kritikos, Onya Opota, Maryline Foerster, René Brouillet, Laurence Senn, Reto Lienhard, Adrian Egli, Giuseppe Pantaleo, Pierre-Nicolas Carron, and Gilbert Greub. 2021. "Implementing SARS-CoV-2 Rapid Antigen Testing in the Emergency Ward of a Swiss University Hospital: The INCREASE Study" Microorganisms 9, no. 4: 798. https://doi.org/10.3390/microorganisms9040798

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop