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Article

Role of Commensal Microbes in the γ-Ray Irradiation-Induced Physiological Changes in Drosophila melanogaster

1
Department of Biological Sciences, Inha University, Incheon 22212, Korea
2
Laboratory of Low Dose Risk Assessment, National Radiation Emergency Medical Center, Korea Institute of Radiological & Medical Sciences, Seoul 01812, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Microorganisms 2021, 9(1), 31; https://doi.org/10.3390/microorganisms9010031
Received: 5 November 2020 / Revised: 19 December 2020 / Accepted: 22 December 2020 / Published: 24 December 2020
(This article belongs to the Special Issue Host–Microbe Interactions in Animal/Human Health and Disease)
Ionizing radiation induces biological/physiological changes and affects commensal microbes, but few studies have examined the relationship between the physiological changes induced by irradiation and commensal microbes. This study investigated the role of commensal microbes in the γ-ray irradiation-induced physiological changes in Drosophila melanogaster. The bacterial load was increased in 5 Gy irradiated flies, but irradiation decreased the number of operational taxonomic units. The mean lifespan of conventional flies showed no significant change by irradiation, whereas that of axenic flies was negatively correlated with the radiation dose. γ-Ray irradiation did not change the average number of eggs in both conventional and axenic flies. Locomotion of conventional flies was decreased after 5 Gy radiation exposure, whereas no significant change in locomotion activity was detected in axenic flies after irradiation. γ-Ray irradiation increased the generation of reactive oxygen species in both conventional and axenic flies, but the increase was higher in axenic flies. Similarly, the amounts of mitochondria were increased in irradiated axenic flies but not in conventional flies. These results suggest that axenic flies are more sensitive in their mitochondrial responses to radiation than conventional flies, and increased sensitivity leads to a reduced lifespan and other physiological changes in axenic flies. View Full-Text
Keywords: γ-ray irradiation; commensal microbes; lifespan; fecundity; locomotion; mitochondria; reactive oxygen species (ROS); Drosophila melanogaster γ-ray irradiation; commensal microbes; lifespan; fecundity; locomotion; mitochondria; reactive oxygen species (ROS); Drosophila melanogaster
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MDPI and ACS Style

Lee, H.-J.; Lee, S.-H.; Lee, J.-H.; Kim, Y.; Seong, K.M.; Jin, Y.W.; Min, K.-J. Role of Commensal Microbes in the γ-Ray Irradiation-Induced Physiological Changes in Drosophila melanogaster. Microorganisms 2021, 9, 31. https://doi.org/10.3390/microorganisms9010031

AMA Style

Lee H-J, Lee S-H, Lee J-H, Kim Y, Seong KM, Jin YW, Min K-J. Role of Commensal Microbes in the γ-Ray Irradiation-Induced Physiological Changes in Drosophila melanogaster. Microorganisms. 2021; 9(1):31. https://doi.org/10.3390/microorganisms9010031

Chicago/Turabian Style

Lee, Hwa-Jin, Shin-Hae Lee, Ji-Hyeon Lee, Yongjoong Kim, Ki M. Seong, Young W. Jin, and Kyung-Jin Min. 2021. "Role of Commensal Microbes in the γ-Ray Irradiation-Induced Physiological Changes in Drosophila melanogaster" Microorganisms 9, no. 1: 31. https://doi.org/10.3390/microorganisms9010031

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