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Open AccessArticle

Effects of Vitamin B2 Supplementation in Broilers Microbiota and Metabolome

1
Unit of Holobiont Microbiome and Microbiome Engineering (HolobioME), Department of Pharmacy and Biotechnology (FABIT), Alma Mater Studiorum—University of Bologna, 40126 Bologna, Italy
2
Department of Agricultural and Food Sciences (DISTAL), Alma Mater Studiorum—University of Bologna, 40127 Bologna, Italy
3
DSM Nutritional Products, Basel, Animal Nutrition and Health, Wurmisweg 576, 4303 Kaiseraugst, Switzerland
4
Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC 3010, Australia
5
Interdepartmental Centre for Industrial AgroFood Research (CIRI-AGRO), Alma Mater Studiorum—University of Bologna, 47521 Cesena, Italy
6
Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum—University of Bologna, 40138 Bologna, Italy
7
Department of Veterinary Medical Sciences (DIMEVET), Alma Mater Studiorum—University of Bologna, 40064 Ozzano dell’Emilia, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to the paper.
Microorganisms 2020, 8(8), 1134; https://doi.org/10.3390/microorganisms8081134
Received: 3 June 2020 / Revised: 24 July 2020 / Accepted: 24 July 2020 / Published: 27 July 2020
(This article belongs to the Special Issue Microbiomes for the Sustainable Production of Safe and Secure Foods)
The study of the microbiome in broiler chickens holds great promise for the development of strategies for health maintenance and performance improvement. Nutritional strategies aimed at modulating the microbiota—host relationship can improve chickens’ immunological status and metabolic fitness. Here, we present the results of a pilot trial aimed at analyzing the effects of a nutritional strategy involving vitamin B2 supplementation on the ileum, caeca and litter microbiota of Ross 308 broilers, as well as on the metabolic profile of the caecal content. Three groups of chickens were administered control diets and diets supplemented with two different dosages of vitamin B2. Ileum, caeca, and litter samples were obtained from subgroups of birds at three time points along the productive cycle. Sequencing of the 16S rRNA V3–V4 region and NMR metabolomics were used to explore microbiota composition and the concentration of metabolites of interest, including short-chain fatty acids. Vitamin B2 supplementation significantly modulated caeca microbiota, with the highest dosage being more effective in increasing the abundance of health-promoting bacterial groups, including Bifidobacterium, resulting in boosted production of butyrate, a well-known health-promoting metabolite, in the caeca environment. View Full-Text
Keywords: broiler; microbiota; metabolome; short chain fatty acids; vitamin B2 broiler; microbiota; metabolome; short chain fatty acids; vitamin B2
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MDPI and ACS Style

Biagi, E.; Mengucci, C.; Barone, M.; Picone, G.; Lucchi, A.; Celi, P.; Litta, G.; Candela, M.; Manfreda, G.; Brigidi, P.; Capozzi, F.; De Cesare, A. Effects of Vitamin B2 Supplementation in Broilers Microbiota and Metabolome. Microorganisms 2020, 8, 1134. https://doi.org/10.3390/microorganisms8081134

AMA Style

Biagi E, Mengucci C, Barone M, Picone G, Lucchi A, Celi P, Litta G, Candela M, Manfreda G, Brigidi P, Capozzi F, De Cesare A. Effects of Vitamin B2 Supplementation in Broilers Microbiota and Metabolome. Microorganisms. 2020; 8(8):1134. https://doi.org/10.3390/microorganisms8081134

Chicago/Turabian Style

Biagi, Elena; Mengucci, Carlo; Barone, Monica; Picone, Gianfranco; Lucchi, Alex; Celi, Pietro; Litta, Gilberto; Candela, Marco; Manfreda, Gerardo; Brigidi, Patrizia; Capozzi, Francesco; De Cesare, Alessandra. 2020. "Effects of Vitamin B2 Supplementation in Broilers Microbiota and Metabolome" Microorganisms 8, no. 8: 1134. https://doi.org/10.3390/microorganisms8081134

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