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Microorganisms
Volume 8
Issue 11
10.3390/microorganisms8111744
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Review

Intestinal Barrier Function in Health and Disease—Any Role of SARS-CoV-2?

by
Lakshya Sharma
1 and
Antonio Riva
1,2,*
1
Faculty of Life Sciences and Medicine, King’s College London, London SE1 1UL, UK
2
Foundation for Liver Research, Institute of Hepatology, London SE5 9NT, UK
*
Author to whom correspondence should be addressed.
Microorganisms 2020, 8(11), 1744; https://doi.org/10.3390/microorganisms8111744
Submission received: 18 October 2020 / Revised: 1 November 2020 / Accepted: 3 November 2020 / Published: 6 November 2020
(This article belongs to the Special Issue The Microbiome/Virome Interface during COVID-19)
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Abstract

Alterations in the structure and function of the intestinal barrier play a role in the pathogenesis of a multitude of diseases. During the recent and ongoing coronavirus disease (COVID-19) pandemic, it has become clear that the gastrointestinal system and the gut barrier may be affected by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, and disruption of barrier functions or intestinal microbial dysbiosis may have an impact on the progression and severity of this new disease. In this review, we aim to provide an overview of current evidence on the involvement of gut alterations in human disease including COVID-19, with a prospective outlook on supportive therapeutic strategies that may be investigated to rescue intestinal barrier functions and possibly facilitate clinical improvement in these patients.
Keywords: gastrointestinal; COVID-19; SARS-CoV-2; microbiota; gut barrier; gut permeability; gut–liver axis; immune; FMT; probiotics gastrointestinal; COVID-19; SARS-CoV-2; microbiota; gut barrier; gut permeability; gut–liver axis; immune; FMT; probiotics

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MDPI and ACS Style

Sharma, L.; Riva, A. Intestinal Barrier Function in Health and Disease—Any Role of SARS-CoV-2? Microorganisms 2020, 8, 1744. https://doi.org/10.3390/microorganisms8111744

AMA Style

Sharma L, Riva A. Intestinal Barrier Function in Health and Disease—Any Role of SARS-CoV-2? Microorganisms. 2020; 8(11):1744. https://doi.org/10.3390/microorganisms8111744

Chicago/Turabian Style

Sharma, Lakshya, and Antonio Riva. 2020. "Intestinal Barrier Function in Health and Disease—Any Role of SARS-CoV-2?" Microorganisms 8, no. 11: 1744. https://doi.org/10.3390/microorganisms8111744

APA Style

Sharma, L., & Riva, A. (2020). Intestinal Barrier Function in Health and Disease—Any Role of SARS-CoV-2? Microorganisms, 8(11), 1744. https://doi.org/10.3390/microorganisms8111744

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