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Control of Francisella tularensis Virulence at Gene Level: Network of Transcription Factors

1
Department of Molecular Pathology and Biology, Faculty of Military Health Sciences, University of Defence, Trebesska 1575, 50001 Hradec Kralove, Czech Republic
2
Department of Clinical Microbiology, Umeå University, SE-901 85 Umeå, Sweden
*
Author to whom correspondence should be addressed.
Microorganisms 2020, 8(10), 1622; https://doi.org/10.3390/microorganisms8101622
Received: 17 September 2020 / Revised: 14 October 2020 / Accepted: 18 October 2020 / Published: 21 October 2020
(This article belongs to the Special Issue Tularemia: Pathogenesis, Diagnostic, Prevention, and Treatment)
Regulation of gene transcription is the initial step in the complex process that controls gene expression within bacteria. Transcriptional control involves the joint effort of RNA polymerases and numerous other regulatory factors. Whether global or local, positive or negative, regulators play an essential role in the bacterial cell. For instance, some regulators specifically modify the transcription of virulence genes, thereby being indispensable to pathogenic bacteria. Here, we provide a comprehensive overview of important transcription factors and DNA-binding proteins described for the virulent bacterium Francisella tularensis, the causative agent of tularemia. This is an unexplored research area, and the poorly described networks of transcription factors merit additional experimental studies to help elucidate the molecular mechanisms of pathogenesis in this bacterium, and how they contribute to disease. View Full-Text
Keywords: Francisella; virulence; transcription factor; pathogenesis; gene regulation Francisella; virulence; transcription factor; pathogenesis; gene regulation
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MDPI and ACS Style

Spidlova, P.; Stojkova, P.; Sjöstedt, A.; Stulik, J. Control of Francisella tularensis Virulence at Gene Level: Network of Transcription Factors. Microorganisms 2020, 8, 1622. https://doi.org/10.3390/microorganisms8101622

AMA Style

Spidlova P, Stojkova P, Sjöstedt A, Stulik J. Control of Francisella tularensis Virulence at Gene Level: Network of Transcription Factors. Microorganisms. 2020; 8(10):1622. https://doi.org/10.3390/microorganisms8101622

Chicago/Turabian Style

Spidlova, Petra; Stojkova, Pavla; Sjöstedt, Anders; Stulik, Jiri. 2020. "Control of Francisella tularensis Virulence at Gene Level: Network of Transcription Factors" Microorganisms 8, no. 10: 1622. https://doi.org/10.3390/microorganisms8101622

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