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Open AccessCommunication

Antibody Response to Toscana Virus and Sandfly Fever Sicilian Virus in Cats Naturally Exposed to Phlebotomine Sand Fly Bites in Portugal

1
Global Health and Tropical Medicine (GHMT), Instituto de Higiene e Medicina Tropical (IHMT), Universidade Nova de Lisboa (UNL), 1349-008 Lisboa, Portugal
2
Medical Parasitology Unit, IHMT-UNL, 1349-008 Lisboa, Portugal
3
Unité des Virus Emergents (UVE: Aix Marseille Univ, IRD 190, INSERM 1207, IHU Méditerranée Infection), 13385 Marseille, France
4
Center for Investigation Vasco da Gama (CIVG), Department of Veterinary Medicine, Vasco da Gama Universitary School, 3020-210 Coimbra, Portugal
5
University Veterinary Hospital of Coimbra, 3020-210 Coimbra, Portugal
6
Animal and Veterinary Research Centre (CECAV), University of Trás-os-Montes and Alto Douro, 5000-801 Vila Real, Portugal
7
Hospital Veterinário da Arrábida, 2925-538 Azeitão, Portugal
8
Hospital Veterinário do Algarve, 8000-072 Faro, Portugal
9
Hospital Veterinário de Berna, 1050-039 Lisboa, Portugal
10
Clínica Veterinária Porto Seguro, 8700-507 Olhão, Portugal
11
VetCoa - Serviços Veterinários, 6320-354 Sabugal, Portugal
12
Department of Parasitology, Faculty of Science, Charles University, 128 00 Prague, Czech Republic
*
Author to whom correspondence should be addressed.
These two authors contributed equally to this work.
Microorganisms 2019, 7(9), 339; https://doi.org/10.3390/microorganisms7090339
Received: 1 August 2019 / Revised: 3 September 2019 / Accepted: 6 September 2019 / Published: 11 September 2019
(This article belongs to the Special Issue Emerging Vector Borne Infections: A Novel Threat for Global Health)
Phlebotomine sand fly-borne pathogens such as Leishmania spp. and phleboviruses are emerging threats to humans and animals worldwide. The aim of this work was to evaluate the exposure of cats from Portugal to Toscana virus (TOSV) and Sandfly Fever Sicilian virus (SFSV) and assess the associated risk factors. The possible association between exposure to Phlebotomus perniciosus saliva with TOSV and SFSV was also investigated. Out of 369 cats tested, 18 (4.9%, n = 365) were seropositive for TOSV, and eight (2.2%, n = 367) were seropositive for SFSV. Multivariate logistic regression analysis showed that cats presenting clinical signs that were compatible with leishmaniosis and antibodies to TOSV had a significantly higher risk of being SFSV seropositive. The presence of antibodies to sand fly-borne viruses in cats indicate that these animals are frequently exposed to sand flies and transmitted pathogens. Data suggest that cats can be used to qualitatively monitor human exposure to TOSV and SFSV in endemic areas. The clinical impact of SFSV in cats’ health should be investigated. The identification of the sand fly species responsible for the circulation of TOSV and SFSV in nature and the evaluation of the vectorial competence of P. perniciosus to SFSV should also be addressed. View Full-Text
Keywords: arbovirus; Bunyavirales; cat; Phenuiviridae; Phlebotomus perniciosus; Phlebovirus; saliva; Sandfly Fever Sicilian Virus; Toscana virus arbovirus; Bunyavirales; cat; Phenuiviridae; Phlebotomus perniciosus; Phlebovirus; saliva; Sandfly Fever Sicilian Virus; Toscana virus
MDPI and ACS Style

Pereira, A.; Ayhan, N.; Cristóvão, J.M.; Vilhena, H.; Martins, Â.; Cachola, P.; Henriques, J.; Coimbra, M.; Catarino, A.; Lestinova, T.; Spitzova, T.; Volf, P.; Campino, L.; Charrel, R.; Maia, C. Antibody Response to Toscana Virus and Sandfly Fever Sicilian Virus in Cats Naturally Exposed to Phlebotomine Sand Fly Bites in Portugal. Microorganisms 2019, 7, 339.

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