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Production of Indole-3-Lactic Acid by Bifidobacterium Strains Isolated fromHuman Infants

Next Generation Science Institute, Morinaga Milk Industry Co., Ltd., Zama, Kanagawa 252-8583, Japan
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Microorganisms 2019, 7(9), 340; https://doi.org/10.3390/microorganisms7090340
Received: 29 July 2019 / Revised: 7 September 2019 / Accepted: 9 September 2019 / Published: 11 September 2019
Recent studies have shown that metabolites produced by microbes can be considered as mediators of host-microbial interactions. In this study, we examined the production of tryptophan metabolites by Bifidobacterium strains found in the gastrointestinal tracts of humans and other animals. Indole-3-lactic acid (ILA) was the only tryptophan metabolite produced in bifidobacteria culture supernatants. No others, including indole-3-propionic acid, indole-3-acetic acid, and indole-3-aldehyde, were produced. Strains of bifidobacterial species commonly isolated from the intestines of human infants, such as Bifidobacterium longum subsp. longum, Bifidobacterium longum subsp. infantis, Bifidobacterium breve, and Bifidobacterium bifidum, produced higher levels of ILA than did strains of other species. These results imply that infant-type bifidobacteria might play a specific role in host–microbial cross-talk by producing ILA in human infants. View Full-Text
Keywords: Bifidobacterium; indole-3-lactic acid; indole-3-propionic acid; indole-3-acetic acid; indole-3-aldehyde Bifidobacterium; indole-3-lactic acid; indole-3-propionic acid; indole-3-acetic acid; indole-3-aldehyde
MDPI and ACS Style

Sakurai, T.; Odamaki, T.; Xiao, J.-Z. Production of Indole-3-Lactic Acid by Bifidobacterium Strains Isolated fromHuman Infants. Microorganisms 2019, 7, 340.

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