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Phage Endolysins as Potential Antimicrobials against Multidrug Resistant Vibrio alginolyticus and Vibrio parahaemolyticus: Current Status of Research and Challenges Ahead

Department of Biotechnology, Cochin University of Science and Technology, Kochi-682022, Kerala, India
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Microorganisms 2019, 7(3), 84; https://doi.org/10.3390/microorganisms7030084
Received: 25 February 2019 / Revised: 14 March 2019 / Accepted: 15 March 2019 / Published: 18 March 2019
(This article belongs to the Special Issue Biocontrol of Food Borne Pathogens)
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Abstract

Vibrio alginolyticus and V. parahaemolyticus, the causative agents of Vibriosis in marine vertebrates and invertebrates, are also responsible for fatal illnesses such as gastroenteritis, septicemia, and necrotizing fasciitis in humans via the ingestion of contaminated seafood. Aquaculture farmers often rely on extensive prophylactic use of antibiotics in farmed fish to mitigate Vibrios and their biofilms. This has been postulated as being of serious concern in the escalation of antibiotic resistant Vibrios. For this reason, alternative strategies to combat aquaculture pathogens are in high demand. Bacteriophage-derived lytic enzymes and proteins are of interest to the scientific community as promising tools with which to diminish our dependency on antibiotics. Lysqdvp001 is the best-characterized endolysin with lytic activity against multiple species of Vibrios. Various homologues of Vibrio phage endolysins have also been studied for their antibacterial potential. These novel endolysins are the major focus of this mini review. View Full-Text
Keywords: antibiotic resistance; endolysin; Vibrio alginolyticus; V. parahaemolyticus antibiotic resistance; endolysin; Vibrio alginolyticus; V. parahaemolyticus
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Matamp, N.; Bhat, S.G. Phage Endolysins as Potential Antimicrobials against Multidrug Resistant Vibrio alginolyticus and Vibrio parahaemolyticus: Current Status of Research and Challenges Ahead. Microorganisms 2019, 7, 84.

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