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Microorganisms
Volume 7
Issue 11
10.3390/microorganisms7110538
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Article

Mitochondria-Mediated Programmed Cell Death in Saccharomyces Cerevisiae Induced by Betulinic Acid is Accelerated by the Deletion of PEP4 Gene

by
Hongyun Lu
†,
Qin Shu
†,
Hanghang Lou
and
Qihe Chen
*
Department of Food Science and Nutrition, Zhejiang University, Hangzhou 310058, China
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Microorganisms 2019, 7(11), 538; https://doi.org/10.3390/microorganisms7110538
Submission received: 13 October 2019 / Revised: 27 October 2019 / Accepted: 5 November 2019 / Published: 7 November 2019
(This article belongs to the Section Microbial Biotechnology)
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Abstract

In this work, using Saccharomyces cerevisiae as a model, we showed that BetA could inhibit cell proliferation and lead to lethal cytotoxicity accompanying programmed cell death (PCD). Interestingly, it was found that vacuolar protease Pep4p played a pivotal role in BetA-induced S. cerevisiae PCD. The presence of Pep4p reduced the damage of BetA-induced cells. This work implied that BetA may induce cell death of S. cerevisiae through mitochondria-mediated PCD, and the deletion of Pep4 gene possibly accelerated the effect of PCD. The present investigation provided the preliminary research for the complicated mechanism of BetA-induced cell PCD regulated by vacular protease Pep4p and lay the foundation for understanding of the Pep4p protein in an animal model.
Keywords: Saccharomyces cerevisiae; Pep4p; betulinic acid; mitochondria-mediated programmed cell death Saccharomyces cerevisiae; Pep4p; betulinic acid; mitochondria-mediated programmed cell death

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MDPI and ACS Style

Lu, H.; Shu, Q.; Lou, H.; Chen, Q. Mitochondria-Mediated Programmed Cell Death in Saccharomyces Cerevisiae Induced by Betulinic Acid is Accelerated by the Deletion of PEP4 Gene. Microorganisms 2019, 7, 538. https://doi.org/10.3390/microorganisms7110538

AMA Style

Lu H, Shu Q, Lou H, Chen Q. Mitochondria-Mediated Programmed Cell Death in Saccharomyces Cerevisiae Induced by Betulinic Acid is Accelerated by the Deletion of PEP4 Gene. Microorganisms. 2019; 7(11):538. https://doi.org/10.3390/microorganisms7110538

Chicago/Turabian Style

Lu, Hongyun, Qin Shu, Hanghang Lou, and Qihe Chen. 2019. "Mitochondria-Mediated Programmed Cell Death in Saccharomyces Cerevisiae Induced by Betulinic Acid is Accelerated by the Deletion of PEP4 Gene" Microorganisms 7, no. 11: 538. https://doi.org/10.3390/microorganisms7110538

APA Style

Lu, H., Shu, Q., Lou, H., & Chen, Q. (2019). Mitochondria-Mediated Programmed Cell Death in Saccharomyces Cerevisiae Induced by Betulinic Acid is Accelerated by the Deletion of PEP4 Gene. Microorganisms, 7(11), 538. https://doi.org/10.3390/microorganisms7110538

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