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Microorganisms 2019, 7(1), 17; https://doi.org/10.3390/microorganisms7010017

Socioeconomic Status and the Gut Microbiome: A TwinsUK Cohort Study

1
The Department of Twin Research, Kings College London, 3-4th Floor South Wing Block D, St Thomas’ Hospital, Westminster Bridge Road, London SE1 7EH, UK
2
Kennedy Institute of Rheumatology, University of Oxford, Oxford OX1 3QR, UK
3
Clinical Age Research Unit, Kings College Hospital Foundation Trust, London SE5 9RS, UK
4
Department of Global Health & Social Medicine, King’s Building, King’s College London, Strand, London WC2R 2LS, UK
5
CUNY Graduate School of Public Health and Health Policy, 55 W 125th Street, New York, NY 10027, USA
6
Department of Ageing and Health, St Thomas’ Hospital, 9th floor, North Wing, Westminster Bridge Road, London SE1 7EH, UK
These authors are co-last-authors.
*
Author to whom correspondence should be addressed.
Received: 19 December 2018 / Revised: 7 January 2019 / Accepted: 8 January 2019 / Published: 11 January 2019
(This article belongs to the Special Issue Gut Microbiota Diversity Relates to Lifestyle)
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Abstract

Socioeconomic inequalities in health and mortality are well established, but the biological mechanisms underlying these associations are less understood. In parallel, the gut microbiome is emerging as a potentially important determinant of human health, but little is known about its broader environmental and social determinants. We test the association between gut microbiota composition and individual- and area-level socioeconomic factors in a well-characterized twin cohort. In this study, 1672 healthy volunteers from twin registry TwinsUK had data available for at least one socioeconomic measure, existing fecal 16S rRNA microbiota data, and all considered co-variables. Associations with socioeconomic status (SES) were robust to adjustment for known health correlates of the microbiome; conversely, these health-microbiome associations partially attenuated with adjustment for SES. Twins discordant for IMD (Index of Multiple Deprivation) were shown to significantly differ by measures of compositional dissimilarity, with suggestion the greater the difference in twin pair IMD, the greater the dissimilarity of their microbiota. Future research should explore how SES might influence the composition of the gut microbiota and its potential role as a mediator of differences associated with SES. View Full-Text
Keywords: microbiome; microbiota; sociobiome; socioeconomic status; SES microbiome; microbiota; sociobiome; socioeconomic status; SES
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Bowyer, R.C.E.; Jackson, M.A.; Le Roy, C.I.; Ni Lochlainn, M.; Spector, T.D.; Dowd, J.B.; Steves, C.J. Socioeconomic Status and the Gut Microbiome: A TwinsUK Cohort Study. Microorganisms 2019, 7, 17.

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