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Microorganisms 2018, 6(3), 78; https://doi.org/10.3390/microorganisms6030078

The Interaction of the Gut Microbiota with the Mucus Barrier in Health and Disease in Human

Mucin Research Group, School of Clinical Sciences, Bristol Royal Infirmary, Level 7, Marlborough Street, Bristol BS2 8HW, UK
Received: 29 June 2018 / Revised: 25 July 2018 / Accepted: 30 July 2018 / Published: 2 August 2018
(This article belongs to the Special Issue Gut Bacteria-Mucus Interaction)
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Abstract

Glycoproteins are major players in the mucus protective barrier in the gastrointestinal and other mucosal surfaces. In particular the mucus glycoproteins, or mucins, are responsible for the protective gel barrier. They are characterized by their high carbohydrate content, present in their variable number, tandem repeat domains. Throughout evolution the mucins have been maintained as integral components of the mucosal barrier, emphasizing their essential biological status. The glycosylation of the mucins is achieved through a series of biosynthetic pathways processes, which generate the wide range of glycans found in these molecules. Thus mucins are decorated with molecules having information in the form of a glycocode. The enteric microbiota interacts with the mucosal mucus barrier in a variety of ways in order to fulfill its many normal processes. How bacteria read the glycocode and link to normal and pathological processes is outlined in the review. View Full-Text
Keywords: gastrointestinal; glycoprotein; glycosylation; glycan; glycocode; microbiota; mucus; mucin; mucosal gastrointestinal; glycoprotein; glycosylation; glycan; glycocode; microbiota; mucus; mucin; mucosal
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Corfield, A.P. The Interaction of the Gut Microbiota with the Mucus Barrier in Health and Disease in Human. Microorganisms 2018, 6, 78.

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