Next Article in Journal
Probiotic Supplementation Improves Gut Microbiota in Chronic Metabolic and Cardio-Cerebrovascular Diseases Among Chinese Adults over 60: Study Using Cross-Sectional and Longitudinal Cohorts
Previous Article in Journal
Development of a Broad-Spectrum Antigen-Capture ELISA Using Combined Anti-p26 Polyclonal and Monoclonal Antibodies for Detection of Equine Infectious Anemia Virus
Previous Article in Special Issue
Outbreak of Vancomycin-Resistant Enterococcus in a NICU: Insights into Molecular Detection and Infection Control
 
 
Article
Peer-Review Record

Comparison of Microbiological Profiles of Primary Hip and Knee Peri-Prosthetic Joint Infections Treated at Specialist Centers Around the World

Microorganisms 2025, 13(7), 1505; https://doi.org/10.3390/microorganisms13071505
by Emin Suha Dedeogullari 1, Pablo Slullitel 2, Isabel Horton 3, Bulent Atilla 1, Saif Salih 4, Paul Monk 5, Ahmet Mazhar Tokgozoglu 1, Michael Goplen 5, Bonita Tsang 4, Martin Buljubasich 2, Hesham Abdelbary 3, Simon Garceau 3 and George Grammatopoulos 3,*
Reviewer 1:
Reviewer 2: Anonymous
Microorganisms 2025, 13(7), 1505; https://doi.org/10.3390/microorganisms13071505
Submission received: 31 March 2025 / Revised: 23 June 2025 / Accepted: 23 June 2025 / Published: 27 June 2025
(This article belongs to the Special Issue Clinical Microbial Infection and Antimicrobial Resistance)

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

Thank you for the opportunity to review this manuscript. The paper is well written, with clear presentation of results and a solid structure throughout. The data presented are highly relevant and offer valuable insights for tailoring prophylaxis, prevention, and treatment protocols in periprosthetic joint infections.

In my opinion, this is an excellent study and fully deserves approval. It would be interesting, in future research, to investigate whether the observed microbiological differences among centers may correlate with different outcomes in DAIR procedures—while acknowledging the numerous potential biases such an analysis would entail.

Congratulations to the authors for this outstanding work.

Author Response

Dear Madam/Sir,
Thank you very much for taking the time to review this manuscript. We are very pleased to
get such kind comments. Your future research suggestion regarding DAIR is very inspiring
and definitely would be a topic of high quality research. Thank you once again for your
valuable insights, and we hope to cross paths again in future projects.

King regards,
Authors 

Reviewer 2 Report

Comments and Suggestions for Authors

The paper is interesting, grammatically well written, and highlights many aspects of the PJI, which is a strong topic. However, there are a few comments that I would like authors to address. 

-First, it's hard to understand when the authors describe a figure. I would suggest that for each figure, the authors will quickly introduce it and then focus on the specific. 

-The authors mention several bacteria listed in Table 1. I would also suggest plotting the main ones that have a significant influence, like E. coli and others, to highlight the differences between countries. 

-About the antibiotic residence, no table or detailed info about a specific type of antibiotic used, which bacteria, etc., could you please provide this info clearly and more specifically?

-Authors describe the vancomycin resistance, but no data are easily reported or described. I suggest that the authors reorganize the information and report more detailed tables and graphs.  This could also help in the discussion section to compare or explain your observation and validate the results. 

 

Author Response

Please see attached file for full response 

Author Response File: Author Response.pdf

Back to TopTop