On the History and Applications of Congenic Strains in Cryptococcus Research
Abstract
:1. Introduction
2. Diversity of Cryptococcus Pathogenic Species
3. The First Cryptococcus Congenic Pair
4. Summary of the Current Congenic Pairs in Cryptococcus
5. Examine the Impact of Mating Type on Virulence and Tissue Tropism
6. Examine the Impact of Mating Type on Morphogenesis
7. Determine the Genetic Factors Contributing to Uniparental Mitochondrial Inheritance
8. Limitations and Improvement of Congenic Pair Construction
9. Concluding Remarks
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Pair Name | JEC20/21 | KN99 | KN3501 | KN433 | XL280 | AIR265 | ||||||
Recipient Parent | B3502 | H99 | B3501 | NIH433 | XL280 | R265 | ||||||
Serotype | D | A | D | D | D | B | ||||||
Mating Type | a | α | a | α | a | α | a | α | a | α | a | α |
Molecular Type | VNIV | VNIV | VNI | VNI | VNIV | VNIV | VNIV | VNIV | VNIV | VNIV | VGII | VGII |
Self-filamentation | - | + | ˗ | ˗ | ˗ | ˗ | ˗ | ˗ | ++ | +++ | - | - |
Bisexual Mating | +++ | +++ | ++ | ++ | +++ | +++ | +++ | +++ | +++ | +++ | + | + |
Virulence (i.n.) | ˧ | ˧ | +++ | +++ | n/a | n/a | n/a | n/a | ++ | ++ | +++ | +++ |
Virulence (i.v.) | + | +˧ | +++ | +++ | + | + | + | +˧ | +++ | +++ | +++ | +++ |
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Chadwick, B.J.; Lin, X. On the History and Applications of Congenic Strains in Cryptococcus Research. Pathogens 2020, 9, 750. https://doi.org/10.3390/pathogens9090750
Chadwick BJ, Lin X. On the History and Applications of Congenic Strains in Cryptococcus Research. Pathogens. 2020; 9(9):750. https://doi.org/10.3390/pathogens9090750
Chicago/Turabian StyleChadwick, Benjamin J., and Xiaorong Lin. 2020. "On the History and Applications of Congenic Strains in Cryptococcus Research" Pathogens 9, no. 9: 750. https://doi.org/10.3390/pathogens9090750