Next Article in Journal
Increasing Resistance and Changes in Distribution of Serotypes of Streptococcus agalactiae in Poland
Next Article in Special Issue
Natural Compounds from the Marine Brown Alga Caulocystis cephalornithos with Potent In Vitro-Activity against the Parasitic Nematode Haemonchus contortus
Previous Article in Journal
The Effect of Natural Feline Coronavirus Infection on the Host Immune Response: A Whole-Transcriptome Analysis of the Mesenteric Lymph Nodes in Cats with and without Feline Infectious Peritonitis
Previous Article in Special Issue
Detection of Intestinal Parasites in Stray Dogs from a Farming and Cattle Region of Northwestern Mexico
Open AccessArticle

Naturally Acquired Humoral Immunity against Malaria Parasites in Non-Human Primates from the Brazilian Amazon, Cerrado and Atlantic Forest

Instituto de Medicina Tropical, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP 05403-000, Brazil
ISGlobal, Hospital Clínic—Universitat de Barcelona, 08036 Barcelona, Spain
Germans Trias i Pujol Health Science Research Institute (IGTP), 08916 Badalona, Spain
Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Fiocruz Rondônia, Porto Velho, RO 76812-245, Brazil
Departamento de Biologia, Universidade Federal de Rondônia, Porto Velho, RO 78900-000, Brazil
Life Sciences, Virginia Commonwealth University, Richmond, VA 23284, USA
Departamento de Laboratórios Especializados, Superintendência de Controle de Endemias, São Paulo, SP 01027-000, Brazil
Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Fiocruz Rio de Janeiro, Rio de Janeiro, RJ 21040-900, Brazil
Departamento de Patologia, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, São Paulo, SP 05508-270, Brazil
Departamento de Pesquisas Aplicadas, Fundação Parque Zoológico de São Paulo, São Paulo, SP 04301-905, Brazil
Institute of Ecology, Nature Research Centre, Vilnius 08412, Lithuania
Departamento de Patologia, Universidade Cruzeiro do Sul, São Paulo, SP 01311-925, Brazil
Departamento de Anatomia Patológica, AC Camargo Cancer Center, São Paulo, SP 01525-001, Brazil
Departamento de Medicina Veterinária, Fundação Universidade Regional de Blumenau, Blumenau, SC 89012-900, Brazil
Projeto Bugio, Centro de Pesquisas Biológicas, Indaial, SC 89130-000, Brazil
Author to whom correspondence should be addressed.
Pathogens 2020, 9(7), 525;
Received: 30 May 2020 / Revised: 24 June 2020 / Accepted: 25 June 2020 / Published: 29 June 2020
(This article belongs to the Special Issue Animal Parasitic Diseases)
Non-human primates (NHPs) have been shown to be infected by parasites of the genus Plasmodium, the etiological agent of malaria in humans, creating potential risks of zoonotic transmission. Plasmodium brasilianum, a parasite species similar to P. malariae of humans, have been described in NHPs from Central and South America, including Brazil. The merozoite surface protein 1 (MSP1), besides being a malaria vaccine candidate, is highly immunogenic. Due to such properties, we tested this protein for the diagnosis of parasite infection. We used recombinant proteins of P. malariae MSP1, as well as of P. falciparum and P. vivax, for the detection of antibodies anti-MSP1 of these parasite species, in the sera of NHPs collected in different regions of Brazil. About 40% of the NHP sera were confirmed as reactive to the proteins of one or more parasite species. A relatively higher number of reactive sera was found in animals from the Atlantic Forest than those from the Amazon region, possibly reflecting the former more intense parasite circulation among NHPs due to their proximity to humans at a higher populational density. The presence of Plasmodium positive NHPs in the surveyed areas, being therefore potential parasite reservoirs, needs to be considered in any malaria surveillance program. View Full-Text
Keywords: malaria; Plasmodium malariae; MSP1; non-human primates; serology; Brazil malaria; Plasmodium malariae; MSP1; non-human primates; serology; Brazil
Show Figures

Figure 1

MDPI and ACS Style

Monteiro, E.F.; Fernandez-Becerra, C.; Araujo, M.S.; Messias, M.R.; Ozaki, L.S.; Duarte, A.M.R.C.; Bueno, M.G.; Catao-Dias, J.L.; Chagas, C.R.F.; Mathias, B.S.; Santos, M.G.; Santos, S.V.; Holcman, M.M.; Souza, J.C., Jr.; Kirchgatter, K. Naturally Acquired Humoral Immunity against Malaria Parasites in Non-Human Primates from the Brazilian Amazon, Cerrado and Atlantic Forest. Pathogens 2020, 9, 525.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop