Next Article in Journal
Genetic Diversity of Babesia bovis MSA-1, MSA-2b and MSA-2c in China
Previous Article in Journal
Efflux MexAB-Mediated Resistance in P. aeruginosa Isolated from Patients with Healthcare Associated Infections
Previous Article in Special Issue
Local Lung Immune Response to Mycobacterium bovis Challenge after BCG and M. bovis Heat-Inactivated Vaccination in European Badger (Meles meles)
Open AccessReview

Development and Challenges in Animal Tuberculosis Vaccination

Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad de León, 24071 León, Spain
Departamento de Sanidad Animal, Instituto de Ganadería de Montaña (CSIC-Universidad de León), Finca Marzanas, Grulleros, 24346 León, Spain
SaBio-Instituto de Investigación en Recursos Cinegéticos IREC (UCLM-CSIC-JCCM), Universidad de Castilla-la Mancha (UCLM), 13071 Ciudad Real, Spain
Indian Council of Agricultural Research (ICAR), New Delhi 110001, India
Departamento de Anatomía y Anatomía Patológica Comparadas y Toxicología. Facultad de Veterinaria. Universidad de Córdoba (UCO), 14014 Córdoba, Spain
Unidad de Enfermedades Infecciosas, Grupo de Virología Clínica y Zoonosis, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Hospital Reina Sofía, Universidad de Córdoba (UCO), 14004 Córdoba, Spain
Author to whom correspondence should be addressed.
Pathogens 2020, 9(6), 472;
Received: 26 May 2020 / Revised: 11 June 2020 / Accepted: 12 June 2020 / Published: 15 June 2020
(This article belongs to the Special Issue Tuberculosis Epidemiology and Control in Multi-Host Systems)
Vaccination with Bacillus Calmette–Guérin (BCG) constituted a major advance in the prevention of human tuberculosis (TB) in the beginning of the past century. BCG has also a clear potential for use in animals and, in particular, in the main domestic species subjected to TB control programs, cattle. Nowadays, the use of BCG vaccination against TB in cattle is not permitted by European Union legislation because BCG can induce a cellular immune response producing diagnostic interference in the eradication programs based on tuberculin single and comparative intradermal tests imposed worldwide. In this review, we recall the history of TB vaccination as well as different vaccine trials and the response to vaccination in both domestic and wild animals. Promising potential inactivated vaccines are also reviewed. Research studies are mainly focused to improve vaccine efficacy, and at the same time to ensure its easy administration, safety and stability in the environment. Great challenges remain, particularly in terms of vaccine candidates and also in the acceptance of vaccination. Vaccination should be included in a strategic plan for integrated control of TB under a “one health” perspective, which also includes other measures such as improved biosafety on farms to avoid or decrease contact between domestic and wild animals or control of wildlife reservoirs to avoid overabundance that may favor infection maintenance. View Full-Text
Keywords: vaccination; tuberculosis; Bacillus Calmette–Guérin (BCG); heat-inactivated Mycobacterium bovis vaccine (HIMB); domestic animal; wildlife vaccination; tuberculosis; Bacillus Calmette–Guérin (BCG); heat-inactivated Mycobacterium bovis vaccine (HIMB); domestic animal; wildlife
MDPI and ACS Style

Balseiro, A.; Thomas, J.; Gortázar, C.; Risalde, M.A. Development and Challenges in Animal Tuberculosis Vaccination. Pathogens 2020, 9, 472.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop