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The Molecular Epidemiology of Echinococcus Infections
Open AccessArticle

Transcriptomic Analysis of the Early Strobilar Development of Echinococcus granulosus

1
Programa de Pós-Graduação em Biologia Celular e Molecular, Universidade Federal do Rio Grande do Sul, Porto Alegre 91501-970, Brazil
2
Laboratório de Biologia Molecular de Cestódeos, Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre 91501-970, Brazil
3
Laboratório Nacional de Computação Científica, Petrópolis, Rio de Janeiro 25651-075, Brazil
*
Author to whom correspondence should be addressed.
Current address: Serviço de Hemoterapia, Irmandade Santa Casa de Misericórdia de Porto Alegre, Porto Alegre 90035-074, Brazil.
Pathogens 2020, 9(6), 465; https://doi.org/10.3390/pathogens9060465
Received: 12 May 2020 / Revised: 7 June 2020 / Accepted: 10 June 2020 / Published: 12 June 2020
(This article belongs to the Special Issue Echinococcus)
Echinococcus granulosus has a complex life cycle involving two mammalian hosts. The transition from one host to another is accompanied by changes in gene expression, and the transcriptional events that underlie this transition have not yet been fully characterized. In this study, RNA-seq was used to compare the transcription profiles of samples from E. granulosus protoscoleces induced in vitro to strobilar development at three time points. We identified 818 differentially expressed genes, which were divided into eight expression clusters formed over the entire 24 h period. An enrichment of gene transcripts with molecular functions of signal transduction, enzymes, and protein modifications was observed upon induction and developmental progression. This transcriptomic study provides insights for understanding the complex life cycle of E. granulosus and contributes for searching for the key genes correlating with the strobilar development, which can be used to identify potential candidates for the development of anthelmintic drugs. View Full-Text
Keywords: Echinococcus granulosus; RNA-seq; transcriptome; strobilar development Echinococcus granulosus; RNA-seq; transcriptome; strobilar development
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MDPI and ACS Style

Debarba, J.A.; Sehabiague, M.P.C.; Monteiro, K.M.; Gerber, A.L.; Vasconcelos, A.T.R.; Ferreira, H.B.; Zaha, A. Transcriptomic Analysis of the Early Strobilar Development of Echinococcus granulosus. Pathogens 2020, 9, 465.

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