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miRNAs: EBV Mechanism for Escaping Host’s Immune Response and Supporting Tumorigenesis

Department of Immunological and Molecular Diagnostics, University Hospital for Infectious Diseases “Dr. Fran Mihaljević”, 10000 Zagreb, Croatia
Division of Molecular Biology, Department of Biology, Faculty of Science, University of Zagreb, 10000 Zagreb, Croatia
Author to whom correspondence should be addressed.
Pathogens 2020, 9(5), 353;
Received: 7 April 2020 / Revised: 25 April 2020 / Accepted: 4 May 2020 / Published: 8 May 2020
(This article belongs to the Section Human Pathogens)
Epstein-Barr virus (EBV) or human herpesvirus 4 (HHV-4) is a ubiquitous human oncogenic virus, and the first human virus found to express microRNAs (miRNAs). Its genome contains two regions encoding more than 40 miRNAs that regulate expression of both viral and human genes. There are numerous evidences that EBV miRNAs impact immune response, affect antigen presentation and recognition, change T- and B-cell communication, drive antibody production during infection, and have a role in cell apoptosis. Moreover, the ability of EBV to induce B-cell transformation and take part in mechanisms of oncogenesis in humans is well known. Although EBV infection is associated with development of various diseases, the role of its miRNAs is still not understood. There is abundant data describing EBV miRNAs in nasopharyngeal carcinoma and several studies that have tried to evaluate their role in gastric carcinoma and lymphoma. This review aims to summarize so far known data about the role of EBV miRNAs in altered regulation of gene expression in human cells in EBV-associated diseases. View Full-Text
Keywords: miRNA; EBV; carcinoma; lymphoma miRNA; EBV; carcinoma; lymphoma
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Židovec Lepej, S.; Matulić, M.; Gršković, P.; Pavlica, M.; Radmanić, L.; Korać, P. miRNAs: EBV Mechanism for Escaping Host’s Immune Response and Supporting Tumorigenesis. Pathogens 2020, 9, 353.

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