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Clinical Outcomes of a Zika Virus Mother–Child Pair Cohort in Spain

1
Paediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d’Hebron, Vall d’Hebron Research Institute, Universitat Autònoma de Barcelona, 08035 Barcelona, Spain
2
Department of Paediatrics, Hospital Universitario La Paz, 28046 Madrid, Spain
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Departament of Microbiology, Hospital Universitari Vall d’Hebron, 08035 Barcelona, Spain
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Unit of Fetal Medicine, Department of Obstetrics, Hospital Universitari Vall d’Hebron, 08035 Barcelona, Spain
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Instituto de Salud Carlos III, 28029 Madrid, Spain
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Department of Neonatology, Hospital Universitario La Paz, 28046 Madrid, Spain
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Department of Obstetrics, Hospital Universitario La Paz, 28046 Madrid, Spain
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Department of Paediatrics, Hospital General Universitario Gregorio Marañón, 28009 Madrid, Spain
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Department of Obstetrics, Hospital General Universitario Gregorio Marañón, 28009 Madrid, Spain
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Department of Paediatrics, Hospital Universitari Josep Trueta, 17007 Girona, Spain
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Hospital Costa del Sol, 29603 Marbella, Spain
12
Department of Paediatrics, Hospital Universitario Clínico San Carlos, 28040 Madrid, Spain
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Pediatric Infectious Diseases Unit, Hospital Universitario 12 de Octubre, Madrid, Instituto de Investigación Hospital 12 de Octubre (imas12), Universidad Complutense, 28041 Madrid, Spain
14
Hospital El Escorial, 28200 Madrid, Spain
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Hospital Severo Ochoa, Leganés, 28911 Madrid, Spain
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University College London Great Ormond Street Institute of Child Health, GOSH NIHR BRC, London WC1N 1EH, UK
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University of Bristol, Bristol BS9 1AF, UK
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Division of Pediatric Infectious Diseases, Department for Woman and Child Health, University of Padova, 35122 Padova, Italy
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Fundació NeNe, 28010 Madrid, Spain
*
Author to whom correspondence should be addressed.
Pathogens 2020, 9(5), 352; https://doi.org/10.3390/pathogens9050352
Received: 6 April 2020 / Revised: 24 April 2020 / Accepted: 29 April 2020 / Published: 7 May 2020
(This article belongs to the Section Human Pathogens)
Background: Zika virus (ZIKV) infection has been associated with congenital microcephaly and other neurodevelopmental abnormalities. There is little published research on the effect of maternal ZIKV infection in a non-endemic European region. We aimed to describe the outcomes of pregnant travelers diagnosed as ZIKV-infected in Spain, and their exposed children. Methods: This prospective observational cohort study of nine referral hospitals enrolled pregnant women (PW) who travelled to endemic areas during their pregnancy or the two previous months, or those whose sexual partners visited endemic areas in the previous 6 months. Infants of ZIKV-infected mothers were followed for about two years. Results: ZIKV infection was diagnosed in 163 PW; 112 (70%) were asymptomatic and 24 (14.7%) were confirmed cases. Among 143 infants, 14 (9.8%) had adverse outcomes during follow-up; three had a congenital Zika syndrome (CZS), and 11 other potential Zika-related outcomes. The overall incidence of CZS was 2.1% (95%CI: 0.4–6.0%), but among infants born to ZIKV-confirmed mothers, this increased to 15.8% (95%CI: 3.4–39.6%). Conclusions: A nearly 10% overall risk of neurologic and hearing adverse outcomes was found in ZIKV-exposed children born to a ZIKV-infected traveler PW. Longer-term follow-up of these children is needed to assess whether there are any later-onset manifestations. View Full-Text
Keywords: zika virus; microcephaly; congenital infection; adverse outcome; arboviruses zika virus; microcephaly; congenital infection; adverse outcome; arboviruses
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Soriano-Arandes, A.; Frick, M.A.; García López-Hortelano, M.; Sulleiro, E.; Rodó, C.; Sánchez-Seco, M.P.; Cabrera-Lafuente, M.; Suy, A.; De la Calle, M.; Santos, M.; Antolin, E.; Viñuela, M.C.; Espiau, M.; Salazar, A.; Guarch-Ibáñez, B.; Vázquez, A.; Navarro-Morón, J.; Ramos-Amador, J.-T.; Martin-Nalda, A.; Dueñas, E.; Blázquez-Gamero, D.; Reques-Cosme, R.; Olabarrieta, I.; Prieto, L.; De Ory, F.; Thorne, C.; Byrne, T.; Ades, A.E.; Ruiz-Burga, E.; Giaquinto, C.; Mellado-Peña, M.J.; García-Alix, A.; Carreras, E.; Soler-Palacín, P. Clinical Outcomes of a Zika Virus Mother–Child Pair Cohort in Spain. Pathogens 2020, 9, 352.

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