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Open AccessArticle

A Cross-Sectional Study of Seroprevalence of Strongyloidiasis in Pregnant Women (Peruvian Amazon Basin)

1
Consultorio El Ballestero, Servicio de Salud Castellano Manchego, 2614 Albacete, Spain
2
Departamento de Medicina Clínica, Universidad Miguel Hernández de Elche, 03550 Alicante, Spain
3
Servicio de Medicina Interna, Hospital General Universitario de Alicante, 03010 Alicante, Spain
4
Centro de Investigación de Recursos Naturales, Universidad Nacional de la Amazonia Peruana, 16001 Iquitos, Peru
5
Laboratorio Clínico. Asociación Civil Selva Amazónica, 16001 Iquitos, Peru
6
Asistente de Investigación, Asociación Civil Selva Amazónica, 16001 Iquitos, Peru
7
Servicio de Enfermedades Infecciosas y Medicina Tropical, Hospital Regional de Loreto, 16001 Iquitos, Peru
8
Laboratorio de Biología Molecular e Inmunología, Unidad Especializada del LIPNAA-CIRNA, Universidad Nacional de la Amazonia Peruana, 16001 Iquitos, Peru
9
Servicio de Microbiologia, Hospital Universitario Príncipe de Asturias, 28802 Alcalá de Henares, Spain
10
División de Enfermedades Infecciosas, Hospital Universitario Fundación Jiménez Díaz, 28040 Madrid, Spain
11
Departamento de Medicina, Universidad Autónoma de Madrid, 28029 Madrid, Spain
12
Departamento Médico, Asociación Cívica Selva Amazónica, 16001 Iquitos, Peru
13
Facultad de Medicina, Universidad Nacional de la Amazonia Peruana, 496 Iquitos, Peru
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Members of the Spanish-Peruvian Chagas, HTLV and Strongyloides Network: J.M. Ramos-Rincón & A. Gimeno (Hospital General Universitario Alicante & Universidad Miguel Hernández, Alicante, Spain), J. Llenas-García (Hospital Vega Baja, Orihuela, Spain), M. Górgolas-Hernández-Mora, R. Pérez-Tanoira & L. Prieto (Hospital Universitario Fundación Jiménez-Díaz & Universidad Autónoma de Madrid, Madrid, Spain), S. Ortiz-Martínez (Consultorio El Ballestero, Albacete, Spain) M.E. Vásquez-Chasnamote (Centro de Investigación de Recursos Naturales, Universidad Nacional de la Amazonia Peruana. Iquitos, Peru), O.N. Gamboa-Paredes, J. Parraguez-de-la-Cruz J.J. Alarcón-Baldeón., P. Schillyk-Guerra, J. Bardales-Vásquez, G. Pérez-Bardales, A. Hernández-Vargas T. Zumaeta Silva, & R.P Pezo-Flores (Asociación Civil Selva Amazónica, Iquitos, Peru), L.A. Espinoza-Venegas (Hospital Regional de Loreto, Iquitos, Peru), V.V. Pinedo Cancino. Laboratorio de Biología Molecular e Inmunología de la Unidad Especializada, Universidad Nacional de la Amazonia Peruana & Asociación Civil Selva Amazónica, Iquitos, Peru) & Martín Casapía Morales. (Hospital Regional de Loreto, & Asociación Civil Selva Amazónica, Universidad Nacional de la Amazonia Peruana, Iquitos, Peru).
Pathogens 2020, 9(5), 348; https://doi.org/10.3390/pathogens9050348
Received: 16 February 2020 / Revised: 28 April 2020 / Accepted: 30 April 2020 / Published: 4 May 2020
(This article belongs to the Special Issue Prevalence of Strongyloidiasis and Schistosomiasis)
Strongyloidiasis is a soil-transmitted helminthiasis with a high global prevalence. Objectives: We aimed to evaluate the prevalence of Strongyloides stercoralis infection and assess strongyloidiasis serology as a screening technique in the Peruvian Amazon. Material and Methods: We performed a cross-sectional study of strongyloidiasis in 300 pregnant women in Iquitos (Peru) from 1 May 2019 to 15 June 2019. Women were tested using serology (Strongyloides IgG IVD-ELISA kit) as an index test and the modified Baermann technique and/or charcoal fecal culture as the parasitological reference standard. Results: The reference tests showed S. stercoralis in the stool of 30 women (prevalence: 10%; 95% confidence interval [CI] 7.1% to 13.9%), while 101 women tested positive on the blood test (prevalence: 33.7%; 95% CI 28.6% to 39.4%). Fourteen of the 15 women (93.3%) with positive results according to the modified Baermann technique, and 14 of the 23 women (56.5%) with positive charcoal cultures also had positive serological results. Serology showed a sensitivity of 63.3% and a negative predictive value of 94.4%. Conclusion: In Iquitos, pregnant women have a high prevalence of S stercoralis. S. stercoralis ELISA could be an excellent tool for population-based screening, as it has a high negative predictive value that can help to rule out the presence of active infection. View Full-Text
Keywords: Strongyloides stercoralis; serology; seroprevalence; prevalence; Peru; Amazon Strongyloides stercoralis; serology; seroprevalence; prevalence; Peru; Amazon
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Ortiz-Martínez, S.; Ramos-Rincón, J.-M.; Vásquez-Chasnamote, M.-E.; Alarcón-Baldeón, J.J.; Parraguez-de-la-Cruz, J.; Gamboa-Paredes, O.-N.; Schillyk-Guerra, P.; Espinoza-Venegas, L.-A.; Pinedo-Cancino, V.-V.; Perez-Tanoira, R.; Górgolas-Hernández-Mora, M.; Casapía-Morales, M.; Spanish-Peruvian Chagas, HTLV and Strongyloides Network. A Cross-Sectional Study of Seroprevalence of Strongyloidiasis in Pregnant Women (Peruvian Amazon Basin). Pathogens 2020, 9, 348.

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