Next Article in Journal
High Prevalence of Strongyloides among South Asian Migrants in Primary Care―Associations with Eosinophilia and Gastrointestinal Symptoms
Previous Article in Journal
Molecular detection of antimalarial drug resistance in Plasmodium vivax from returned travellers to NSW, Australia during 2008–2018
Open AccessArticle

Effect and Analysis of Bacterial Lysates for the Treatment of Recurrent Urinary Tract Infections in Adults

1
Doctorado en Ciencias Biológicas, Universidad Autónoma de Querétaro, Querétaro 76230, México
2
Laboratorio de Patogenicidad Bacteriana, Unidad de Hemato-Oncología e Investigación Hospital Infantil de México Federico Gómez/División de Investigación, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México 06720, México
3
Departamento de Salud Pública, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México 04510, México
4
Facultad de Ciencias Naturales-Universidad Autónoma de Querétaro, Querétaro 76230, México
5
Laboratorio de Biología Molecular, Departamento de Producción Agrícola y Animal, Universidad Autónoma Metropolitana Xochimilco, Ciudad de México 04960, México
6
Laboratorio de Investigación en Inmunología y Proteómica, Sección de Biología Celular de Linfocitos Unidad de Hemato-Oncología e Investigación Hospital Infantil de México, Federico Gómez, Ciudad de México 06720, México
*
Authors to whom correspondence should be addressed.
Pathogens 2020, 9(2), 102; https://doi.org/10.3390/pathogens9020102
Received: 10 December 2019 / Revised: 28 January 2020 / Accepted: 3 February 2020 / Published: 6 February 2020
(This article belongs to the Section Vaccines and Therapeutic Developments)
Urinary tract infection (UTI) is a relevant public health problem, economically and socially affecting the lives of patients. The increase of antimicrobial bacterial resistance significantly hinders the treatment of UTIs, raising the need to search for alternative therapies. Bacterial lysates (BL) obtained from Escherichia coli and other pathogens have been used to treat different infectious diseases with promising results. This work aims to evaluate the effect and composition of an autologous BL for the treatment and control of recurrent UTIs in adults. The results show remission in 70% of the patients within the first three months after the administration of BL, while the infection is maintained under control for 6–12 months. The analysis by liquid chromatography–mass spectrometry (LC-MS) of the BL fractions recognized by the sera of patients shows the presence of cytosolic proteins, fimbriae, OMPs, and LPS. Our study demonstrates that the autologous BL contributed to the treatment and control of recurrent UTIs in adults, and its composition shows that different surface components of E. coli are potential immunogens that could be used to create a polyvalent protective vaccine.
Keywords: uropathogenic E. coli; recurrent UTI; bacterial lysates uropathogenic E. coli; recurrent UTI; bacterial lysates
MDPI and ACS Style

Ahumada-Cota, R.E.; Hernandez-Chiñas, U.; Milián-Suazo, F.; Chávez-Berrocal, M.E.; Navarro-Ocaña, A.; Martínez-Gómez, D.; Patiño-López, G.; Salazar-Jiménez, E.P.; Eslava, C.A. Effect and Analysis of Bacterial Lysates for the Treatment of Recurrent Urinary Tract Infections in Adults. Pathogens 2020, 9, 102.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop