Next Article in Journal
Molecular detection of antimalarial drug resistance in Plasmodium vivax from returned travellers to NSW, Australia during 2008–2018
Previous Article in Journal
Comparison of the Transcriptome Response within the Swine Tracheobronchial Lymphnode Following Infection with PRRSV, PCV-2 or IAV-S.
Previous Article in Special Issue
Evolutionary Insight into the Trypanosomatidae Using Alignment-Free Phylogenomics of the Kinetoplast
Open AccessArticle

Common Structural Patterns in the Maxicircle Divergent Region of Trypanosomatidae

1
Faculty of Biology, M. V. Lomonosov Moscow State University, Moscow 119991, Russia
2
Martsinovsky Institute of Medical Parasitology, Tropical and Vector Borne Diseases, Sechenov University, Moscow 119435, Russia
3
Institute for Information Transmission Problems, Russian Academy of Sciences, Moscow 127051, Russia
4
Life Science Research Centre, Faculty of Science, University of Ostrava, 710 00 Ostrava, Czech Republic
*
Authors to whom correspondence should be addressed.
Pathogens 2020, 9(2), 100; https://doi.org/10.3390/pathogens9020100
Received: 9 January 2020 / Revised: 1 February 2020 / Accepted: 3 February 2020 / Published: 5 February 2020
(This article belongs to the Special Issue Kinetoplastid Phylogenomics and Evolution)
Maxicircles of all kinetoplastid flagellates are functional analogs of mitochondrial genome of other eukaryotes. They consist of two distinct parts, called the coding region and the divergent region (DR). The DR is composed of highly repetitive sequences and, as such, remains the least explored segment of a trypanosomatid genome. It is extremely difficult to sequence and assemble, that is why very few full length maxicircle sequences were available until now. Using PacBio data, we assembled 17 complete maxicircles from different species of trypanosomatids. Here we present their large-scale comparative analysis and describe common patterns of DR organization in trypanosomatids. View Full-Text
Keywords: divergent region; maxicircle; kinetoplast; trypanosomatids; repeats; genomic rearrangements; mitochondrion divergent region; maxicircle; kinetoplast; trypanosomatids; repeats; genomic rearrangements; mitochondrion
Show Figures

Figure 1

MDPI and ACS Style

Gerasimov, E.S.; Zamyatnina, K.A.; Matveeva, N.S.; Rudenskaya, Y.A.; Kraeva, N.; Kolesnikov, A.A.; Yurchenko, V. Common Structural Patterns in the Maxicircle Divergent Region of Trypanosomatidae. Pathogens 2020, 9, 100.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop