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Volume 9
Issue 11
10.3390/pathogens9110925
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Review

RNA Secondary Structure as a First Step for Rational Design of the Oligonucleotides towards Inhibition of Influenza A Virus Replication

by
Marta Szabat
*,
Dagny Lorent
,
Tomasz Czapik
,
Maria Tomaszewska
,
Elzbieta Kierzek
and
Ryszard Kierzek
*
Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704 Poznan, Poland
*
Authors to whom correspondence should be addressed.
Pathogens 2020, 9(11), 925; https://doi.org/10.3390/pathogens9110925
Submission received: 23 October 2020 / Revised: 5 November 2020 / Accepted: 5 November 2020 / Published: 7 November 2020
(This article belongs to the Special Issue Advance in Influenza A Virus)
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Abstract

Influenza is an important research subject around the world because of its threat to humanity. Influenza A virus (IAV) causes seasonal epidemics and sporadic, but dangerous pandemics. A rapid antigen changes and recombination of the viral RNA genome contribute to the reduced effectiveness of vaccination and anti-influenza drugs. Hence, there is a necessity to develop new antiviral drugs and strategies to limit the influenza spread. IAV is a single-stranded negative sense RNA virus with a genome (viral RNA—vRNA) consisting of eight segments. Segments within influenza virion are assembled into viral ribonucleoprotein (vRNP) complexes that are independent transcription-replication units. Each step in the influenza life cycle is regulated by the RNA and is dependent on its interplay and dynamics. Therefore, viral RNA can be a proper target to design novel therapeutics. Here, we briefly described examples of anti-influenza strategies based on the antisense oligonucleotide (ASO), small interfering RNA (siRNA), microRNA (miRNA) and catalytic nucleic acids. In particular we focused on the vRNA structure-function relationship as well as presented the advantages of using secondary structure information in predicting therapeutic targets and the potential future of this field.
Keywords: influenza A virus; RNA structure; replication; antiviral strategies; RNA interference; antisense oligonucleotides; catalytic nucleic acids influenza A virus; RNA structure; replication; antiviral strategies; RNA interference; antisense oligonucleotides; catalytic nucleic acids

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MDPI and ACS Style

Szabat, M.; Lorent, D.; Czapik, T.; Tomaszewska, M.; Kierzek, E.; Kierzek, R. RNA Secondary Structure as a First Step for Rational Design of the Oligonucleotides towards Inhibition of Influenza A Virus Replication. Pathogens 2020, 9, 925. https://doi.org/10.3390/pathogens9110925

AMA Style

Szabat M, Lorent D, Czapik T, Tomaszewska M, Kierzek E, Kierzek R. RNA Secondary Structure as a First Step for Rational Design of the Oligonucleotides towards Inhibition of Influenza A Virus Replication. Pathogens. 2020; 9(11):925. https://doi.org/10.3390/pathogens9110925

Chicago/Turabian Style

Szabat, Marta, Dagny Lorent, Tomasz Czapik, Maria Tomaszewska, Elzbieta Kierzek, and Ryszard Kierzek. 2020. "RNA Secondary Structure as a First Step for Rational Design of the Oligonucleotides towards Inhibition of Influenza A Virus Replication" Pathogens 9, no. 11: 925. https://doi.org/10.3390/pathogens9110925

APA Style

Szabat, M., Lorent, D., Czapik, T., Tomaszewska, M., Kierzek, E., & Kierzek, R. (2020). RNA Secondary Structure as a First Step for Rational Design of the Oligonucleotides towards Inhibition of Influenza A Virus Replication. Pathogens, 9(11), 925. https://doi.org/10.3390/pathogens9110925

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