Next Article in Journal
The Notorious Soilborne Pathogenic Fungus Sclerotinia sclerotiorum: An Update on Genes Studied with Mutant Analysis
Previous Article in Journal
Dichotomy in Fatal Outcomes in a Large Cohort of People Living with HTLV-1 in São Paulo, Brazil
Open AccessArticle

Phylogenomic Analysis of Two Co-Circulating Canine Distemper Virus Lineages in Colombia

1
Grupo de Investigación en Ciencias Animales—GRICA, Facultad de Medicina Veterinaria y Zootecnia, Universidad Cooperativa de Colombia, sede Bucaramanga, Calle 30A # 33-51, 680002 Bucaramanga, Colombia
2
Grupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia, Calle 70 No. 52-21, 050010 Medellín, Colombia
*
Author to whom correspondence should be addressed.
Pathogens 2020, 9(1), 26; https://doi.org/10.3390/pathogens9010026
Received: 28 November 2019 / Revised: 16 December 2019 / Accepted: 18 December 2019 / Published: 27 December 2019
(This article belongs to the Special Issue Canine Distemper Virus Infection)
Canine distemper virus (CDV) is considered a reemerging disease-causing agent in domestic dogs because it presents high divergence among circulating strains worldwide. In Colombia, the South America-3 and South America/North America-4 lineages co-circulate in domestic dogs, both in the Medellin metropolitan area. In this paper, two full CDV genomes from each viral lineage circulating in Medellin were sequenced; we explored the phylogenetic relationship with the available genome sequences; we described the presence of CDV mutations in the South America-3 and South America/North America-4 lineages associated with adaptation to human cells and a crossing of the species barrier and pathogenicity; and we established the evolutionary rates and time of the closest common ancestor for each gene and characterized the presentation of multiple genomic sites by positive selection. View Full-Text
Keywords: phylogenomics; reemerging; lineages co-circulation; genome CDV phylogenomics; reemerging; lineages co-circulation; genome CDV
Show Figures

Figure 1

MDPI and ACS Style

Duque-Valencia, J.; Diaz, F.J.; Ruiz-Saenz, J. Phylogenomic Analysis of Two Co-Circulating Canine Distemper Virus Lineages in Colombia. Pathogens 2020, 9, 26.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop