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In Vitro Benznidazole and Nifurtimox Susceptibility Profile of Trypanosoma cruzi Strains Belonging to Discrete Typing Units TcI, TcII, and TcV

1
Institute of Health Diagnostic and Research Laboratory Services (SELADIS), Faculty of Pharmaceutical and Biochemical Sciences, San Andrés’ Major University, 2008 La Paz, Bolivia
2
IRD, Montpellier University, InterTryp, 34000 Montpellier, France
3
Center for Research on Health in Latin America (CISeAL), School of Biological Sciences, Pontifical Catholic University of Ecuador, 17 01 21 84 Quito, Ecuador
4
IRD, Montpellier University, MiVegec, 34000 Montpellier, France
*
Author to whom correspondence should be addressed.
Equal contribution.
Pathogens 2019, 8(4), 197; https://doi.org/10.3390/pathogens8040197
Received: 26 September 2019 / Revised: 14 October 2019 / Accepted: 15 October 2019 / Published: 19 October 2019
(This article belongs to the Section Human Pathogens)
We ascertain the in vitro Benznidazole (BZN) and Nifurtimox (NFX) susceptibility pattern of epimastigotes, trypomastigotes, and amastigotes of 21 T. cruzi strains, from patients, reservoir, and triatomine bugs of various geographic origins. Using this panel of isolates, we compute the Epidemiological cut off value (COwt). Then, the frequency of the susceptible phenotype (Wild type) towards benznidazole (BZN) and nifurtimox (NFX) within this set of strains belonging to three discrete typing units (DTUs), TcI, TcII, and TcV, was deduced. We observed that the susceptibility status of individual T. cruzi isolates toward BZN and NFX is related to the genetic background and underlying factors that are probably related to the individual life trait history of each strain. Analyzing drug susceptibility in this conceptual framework would offer the possibility to evidence a link between isolates expressing a low susceptibility level (not wild-type) as defined by the COwt value and none-curative treatment. It will also permit us to track drug-resistant parasites in the T. cruzi population. View Full-Text
Keywords: chagas disease; Trypanosoma cruzi; benznidazole; nifurtimox; antimicrobial susceptibility test chagas disease; Trypanosoma cruzi; benznidazole; nifurtimox; antimicrobial susceptibility test
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Revollo, S.; Oury, B.; Vela, A.; Tibayrenc, M.; Sereno, D. In Vitro Benznidazole and Nifurtimox Susceptibility Profile of Trypanosoma cruzi Strains Belonging to Discrete Typing Units TcI, TcII, and TcV. Pathogens 2019, 8, 197.

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