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Staphylococcus aureus Lipoprotein Induces Skin Inflammation, Accompanied with IFN-γ-Producing T Cell Accumulation through Dermal Dendritic Cells

by Suguru Saito 1,2,* and Ali F. Quadery 3
1
Division of Clinical Nephrology and Rheumatology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Niigata 9518510, Japan
2
Institute of Bio Medical Science, Academia Sinica, Taipei 115, Taiwan
3
Biofluid Biomarker Center, Niigata University, Niigata 9502181, Japan
*
Author to whom correspondence should be addressed.
Pathogens 2018, 7(3), 64; https://doi.org/10.3390/pathogens7030064
Received: 2 July 2018 / Revised: 27 July 2018 / Accepted: 27 July 2018 / Published: 29 July 2018
Staphylococcus aureus (S. aureus) is a commensal bacteria on the human skin, which causes serious skin inflammation. Several immune cells, especially effector T cells (Teff), have been identified as key players in S. aureus-derived skin inflammation. However, the bacterial component that induces dramatic host immune responses on the skin has not been well characterized. Here, we report that S. aureus lipoprotein (SA-LP) was recognized by the host immune system as a strong antigen, so this response induced severe skin inflammation. SA-LP activated dendritic cells (DCs), and this activation led to Teff accumulation on the inflamed skin in the murine intradermal (ID) injection model. The skin-accumulated Teff pool was established by IFN-ɤ-producing CD4+ and CD8+T (Th1 and Tc1). SA-LP activated dermal DC (DDC) in a dominant manner, so that these DCs were presumed to possess the strong responsibility of SA-LP-specific Teff generation in the skin-draining lymph nodes (dLN). SA-LP activated DC transfer into the mice ear, which showed similar inflammation, accompanied with Th1 and Tc1 accumulation on the skin. Thus, we revealed that SA-LP has a strong potential ability to establish skin inflammation through the DC-Teff axis. This finding provides novel insights not only for therapy, but also for the prevention of S. aureus-derived skin inflammation. View Full-Text
Keywords: S. aureus; lipoprotein; skin inflammation; dendritic cell; effector T cell S. aureus; lipoprotein; skin inflammation; dendritic cell; effector T cell
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Saito, S.; F. Quadery, A. Staphylococcus aureus Lipoprotein Induces Skin Inflammation, Accompanied with IFN-γ-Producing T Cell Accumulation through Dermal Dendritic Cells. Pathogens 2018, 7, 64.

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