Next Article in Journal
The Listeria monocytogenes Key Virulence Determinants hly and prfA are involved in Biofilm Formation and Aggregation but not Colonization of Fresh Produce
Next Article in Special Issue
Pathogenesis and Animal Models of Post-Primary (Bronchogenic) Tuberculosis, A Review
Previous Article in Journal
On the Demographic and Selective Forces Shaping Patterns of Human Cytomegalovirus Variation within Hosts
Open AccessEditor’s ChoiceReview

Mycobacterium tuberculosis Molecular Determinants of Infection, Survival Strategies, and Vulnerable Targets

Department of Pharmaceutical Sciences, Università del Piemonte Orientale “A. Avogadro”, Largo Donegani 2, 28100 Novara, Italy
*
Author to whom correspondence should be addressed.
Pathogens 2018, 7(1), 17; https://doi.org/10.3390/pathogens7010017
Received: 27 December 2017 / Revised: 26 January 2018 / Accepted: 28 January 2018 / Published: 1 February 2018
(This article belongs to the Special Issue Mechanisms of Mycobacterium tuberculosis Pathogenesis)
Mycobacterium tuberculosis is the causative agent of tuberculosis, an ancient disease which, still today, represents a major threat for the world population. Despite the advances in medicine and the development of effective antitubercular drugs, the cure of tuberculosis involves prolonged therapies which complicate the compliance and monitoring of drug administration and treatment. Moreover, the only available antitubercular vaccine fails to provide an effective shield against adult lung tuberculosis, which is the most prevalent form. Hence, there is a pressing need for effective antitubercular drugs and vaccines. This review highlights recent advances in the study of selected M. tuberculosis key molecular determinants of infection and vulnerable targets whose structures could be exploited for the development of new antitubercular agents. View Full-Text
Keywords: Mycobacterium tuberculosis; tuberculosis; antitubercular drugs; target identification; drug discovery Mycobacterium tuberculosis; tuberculosis; antitubercular drugs; target identification; drug discovery
Show Figures

Figure 1

MDPI and ACS Style

Ferraris, D.M.; Miggiano, R.; Rossi, F.; Rizzi, M. Mycobacterium tuberculosis Molecular Determinants of Infection, Survival Strategies, and Vulnerable Targets. Pathogens 2018, 7, 17.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop