Next Article in Journal
Mycobacterium tuberculosis Molecular Determinants of Infection, Survival Strategies, and Vulnerable Targets
Next Article in Special Issue
Navigating the Host Cell Response during Entry into Sites of Latent Cytomegalovirus Infection
Previous Article in Journal
Antifungal Activity of Commercial Essential Oils and Biocides against Candida Albicans
Article Menu

Export Article

Open AccessReview
Pathogens 2018, 7(1), 16; https://doi.org/10.3390/pathogens7010016

On the Demographic and Selective Forces Shaping Patterns of Human Cytomegalovirus Variation within Hosts

1
School of Life Sciences, Arizona State University, Tempe, AZ 85281, USA
2
Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655, USA
*
Author to whom correspondence should be addressed.
Received: 10 January 2018 / Revised: 23 January 2018 / Accepted: 25 January 2018 / Published: 28 January 2018
(This article belongs to the Special Issue Cytomegalovirus Infection)
Full-Text   |   PDF [533 KB, uploaded 28 January 2018]   |  

Abstract

Human cytomegalovirus (HCMV) is a member of the β -herpesvirus subfamily within Herpesviridae that is nearly ubiquitous in human populations, and infection generally results only in mild symptoms. However, symptoms can be severe in immunonaive individuals, and transplacental congenital infection of HCMV can result in serious neurological sequelae. Recent work has revealed much about the demographic and selective forces shaping the evolution of congenitally transmitted HCMV both on the level of hosts and within host compartments, providing insight into the dynamics of congenital infection, reinfection, and evolution of HCMV with important implications for the development of effective treatments and vaccines. View Full-Text
Keywords: human cytomegalovirus; population genetics; viral evolution human cytomegalovirus; population genetics; viral evolution
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Sackman, A.M.; Pfeifer, S.P.; Kowalik, T.F.; Jensen, J.D. On the Demographic and Selective Forces Shaping Patterns of Human Cytomegalovirus Variation within Hosts. Pathogens 2018, 7, 16.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Pathogens EISSN 2076-0817 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top