Next Article in Journal
Parasitic Nematode Immunomodulatory Strategies: Recent Advances and Perspectives
Next Article in Special Issue
Molecular Epidemiology and Spatio-Temporal Dynamics of the H3N8 Equine Influenza Virus in South America
Previous Article in Journal / Special Issue
Retrospective Analysis of the Equine Influenza Virus A/Equine/Kirgizia/26/1974 (H7N7) Isolated in Central Asia
Open AccessReview

The Influenza NS1 Protein: What Do We Know in Equine Influenza Virus Pathogenesis?

by Marta Barba 1 and Janet M. Daly 2,*
1
Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA
2
School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington LE12 5RD, UK
*
Author to whom correspondence should be addressed.
Academic Editor: Lawrence S. Young
Pathogens 2016, 5(3), 57; https://doi.org/10.3390/pathogens5030057
Received: 11 June 2016 / Revised: 24 August 2016 / Accepted: 27 August 2016 / Published: 31 August 2016
(This article belongs to the Special Issue Equine Influenza)
Equine influenza virus remains a serious health and potential economic problem throughout most parts of the world, despite intensive vaccination programs in some horse populations. The influenza non-structural protein 1 (NS1) has multiple functions involved in the regulation of several cellular and viral processes during influenza infection. We review the strategies that NS1 uses to facilitate virus replication and inhibit antiviral responses in the host, including sequestering of double-stranded RNA, direct modulation of protein kinase R activity and inhibition of transcription and translation of host antiviral response genes such as type I interferon. Details are provided regarding what it is known about NS1 in equine influenza, especially concerning C-terminal truncation. Further research is needed to determine the role of NS1 in equine influenza infection, which will help to understand the pathophysiology of complicated cases related to cytokine imbalance and secondary bacterial infection, and to investigate new therapeutic and vaccination strategies. View Full-Text
Keywords: non-structural protein; equine influenza; pathogenicity; interspecies transmission non-structural protein; equine influenza; pathogenicity; interspecies transmission
Show Figures

Figure 1

MDPI and ACS Style

Barba, M.; Daly, J.M. The Influenza NS1 Protein: What Do We Know in Equine Influenza Virus Pathogenesis? Pathogens 2016, 5, 57.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop