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Immune Response to Human Metapneumovirus Infection: What We Have Learned from the Mouse Model

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Department of Pathobiological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA
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Center for Experimental Infectious Diseases Research, Louisiana State University, Baton Rouge, LA 70803, USA
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Author to whom correspondence should be addressed.
Academic Editor: Moriya Tsuji
Pathogens 2015, 4(3), 682-696; https://doi.org/10.3390/pathogens4030682
Received: 19 June 2015 / Revised: 9 September 2015 / Accepted: 15 September 2015 / Published: 18 September 2015
(This article belongs to the Special Issue Animal Model to Study Viral Immunity)
Human Metapneumovirus (hMPV) is a leading respiratory viral pathogen associated with bronchiolitis, pneumonia, and asthma exacerbation in young children, the elderly and immunocompromised individuals. The development of a potential vaccine against hMPV requires detailed understanding of the host immune system, which plays a significant role in hMPV pathogenesis, susceptibility and vaccine efficacy. As a result, animal models have been developed to better understand the mechanisms by which hMPV causes disease. Several animal models have been evaluated and established so far to study the host immune responses and pathophysiology of hMPV infection. However, inbred laboratory mouse strains have been one of the most used animal species for experimental modeling and therefore used for the studies of immunity and immunopathogenesis to hMPV. This review summarizes the contributions of the mouse model to our understanding of the immune response against hMPV infection. View Full-Text
Keywords: human metapneumovirus; paramyxovirus; mouse model; immune responses human metapneumovirus; paramyxovirus; mouse model; immune responses
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Cheemarla, N.R.; Guerrero-Plata, A. Immune Response to Human Metapneumovirus Infection: What We Have Learned from the Mouse Model. Pathogens 2015, 4, 682-696.

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