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Volume 12
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10.3390/pathogens12080973
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Article

Prognostic Value of Creatinine Levels at Admission on Disease Progression and Mortality in Patients with COVID-19—An Observational Retrospective Study

by
Antonio Russo
1,
Mariantonietta Pisaturo
1,
Caterina Monari
1,
Federica Ciminelli
1,
Paolo Maggi
2,
Enrico Allegorico
3,
Ivan Gentile
4,
Vincenzo Sangiovanni
5,
Vincenzo Esposito
6,
Valeria Gentile
7,
Giosuele Calabria
8,
Raffaella Pisapia
9,
Canio Carriero
10,
Alfonso Masullo
11,
Elio Manzillo
12,
Grazia Russo
13,
Roberto Parrella
14,
Giuseppina Dell’Aquila
15,
Michele Gambardella
16,
Antonio Ponticiello
17,
Lorenzo Onorato
1 and
Nicola Coppola
1,*,† on behalf of the CoviCamp Groupadd Show full author list remove Hide full author list
1
Infectious Diseases, Department of Mental Health and Public Medicine, University of Campania “L. Vanvitelli”, 80138 Naples, Italy
2
Infectious Diseases Unit, A.O. S Anna e S Sebastiano Caserta, 81100 Caserta, Italy
3
Emergency Unit, P.O. Santa Maria delle Grazie, 80078 Pozzuoli, Italy
4
Infectious Disease Unit, University Federico II, 80138 Naples, Italy
5
Third Infectious Diseases Unit, AORN dei Colli, P.O. Cotugno, 80131 Naples, Italy
6
IV Infectious Disease Unit, AORN dei Coli, P.O. Cotugno, 80131 Naples, Italy
7
Hepatic Infectious Disease Unit, AORN dei Colli, P.O. Cotugno, 80131 Naples, Italy
8
IX Infectious Disease Unit, AORN dei Coli, P.O. Cotugno, 80131 Naples, Italy
9
First Infectious Disease Unit, AORN dei Coli, P.O. Cotugno, 80131 Naples, Italy
10
Department of Infectious Diseases, AORN S. Pio “G. Rummo” General Hospital, 82100 Benevento, Italy
11
Infectious Disease Unit, A.O. San Giovanni di Dio e Ruggi D’Aragona Salerno, 84131 Salerno, Italy
12
VIII Infectious Disease Unit, AORN dei Coli, P.O. Cotugno, 80131 Naples, Italy
13
Infectious Disease Unit, Ospedale Maria S.S. Addolorata di Eboli, ASL Salerno, 84025 Eboli, Italy
14
Respiratory Infectious Disease Unit, AORN dei Colli, P.O. Cotugno, 80131 Naples, Italy
15
Infectious Disease Unit, A.O. Avellino, 83100 Avellino, Italy
16
Infectious Disease Unit, P.O. S. Luca, Vallo della Lucania, ASL Salerno, 84078 Salerno, Italy
17
Pneumology Unit, AORN Caserta, 81100 Caserta, Italy
 
add Show full affiliation list
 
remove Hide full affiliation list
*
Author to whom correspondence should be addressed.
†
Collaborators of the CoviCamp Group are indicated in the Acknowledgment section.
Pathogens 2023, 12(8), 973; https://doi.org/10.3390/pathogens12080973
Submission received: 12 June 2023 / Revised: 18 July 2023 / Accepted: 22 July 2023 / Published: 25 July 2023
(This article belongs to the Topic Host Response against SARS-CoV-2 Infection: Implications for Diagnosis, Treatment and Vaccine Development)
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Abstract

Introduction: Acute kidney disease and chronic kidney disease are considered conditions that can increase the mortality and severity of COVID-19. However, few studies have investigated the impact of creatinine levels on COVID-19 progression in patients without a history of chronic kidney disease. The aim of the study was to assess the impact of creatinine levels at hospital admission on COVID-19 progression and mortality. Methods: We performed a multicenter, observational, retrospective study involving seventeen COVID-19 Units in the Campania region in southern Italy. All adult (≥18 years) patients, hospitalized with a diagnosis of SARS-CoV-2 infection confirmed by a positive reverse transcriptase-polymerase chain reaction on a naso-oropharyngeal swab, from 28 February 2020 to 31 May 2021, were enrolled in the CoviCamp cohort. Results: Evaluating inclusion/exclusion criteria, 1357 patients were included. Considering in-hospital mortality and creatinine value at admission, the best cut-off point to discriminate a death during hospitalization was 1.115 mg/dL. The logistic regression demonstrated that factors independently associated with mortality were age (OR 1.082, CI: 1.054–1.110), Charlson Comorbidity Index (CCI) (OR 1.341, CI: 1.178–1.526), and an abnormal creatinine value at admission, defined as equal to or above 1.12 mg/dL (OR 2.233, CI: 1.373–3.634). Discussion: In conclusion, our study is in line with previous studies confirming that the creatinine serum level can predict mortality in COVID-19 patients and defining that the best cut-off of the creatinine serum level at admission to predict mortality was 1.12 mg/dL.
Keywords: creatinine; kidney disease; COVID-19; SARS-CoV-2 infection; outcome; mortality creatinine; kidney disease; COVID-19; SARS-CoV-2 infection; outcome; mortality

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MDPI and ACS Style

Russo, A.; Pisaturo, M.; Monari, C.; Ciminelli, F.; Maggi, P.; Allegorico, E.; Gentile, I.; Sangiovanni, V.; Esposito, V.; Gentile, V.; et al. Prognostic Value of Creatinine Levels at Admission on Disease Progression and Mortality in Patients with COVID-19—An Observational Retrospective Study. Pathogens 2023, 12, 973. https://doi.org/10.3390/pathogens12080973

AMA Style

Russo A, Pisaturo M, Monari C, Ciminelli F, Maggi P, Allegorico E, Gentile I, Sangiovanni V, Esposito V, Gentile V, et al. Prognostic Value of Creatinine Levels at Admission on Disease Progression and Mortality in Patients with COVID-19—An Observational Retrospective Study. Pathogens. 2023; 12(8):973. https://doi.org/10.3390/pathogens12080973

Chicago/Turabian Style

Russo, Antonio, Mariantonietta Pisaturo, Caterina Monari, Federica Ciminelli, Paolo Maggi, Enrico Allegorico, Ivan Gentile, Vincenzo Sangiovanni, Vincenzo Esposito, Valeria Gentile, and et al. 2023. "Prognostic Value of Creatinine Levels at Admission on Disease Progression and Mortality in Patients with COVID-19—An Observational Retrospective Study" Pathogens 12, no. 8: 973. https://doi.org/10.3390/pathogens12080973

APA Style

Russo, A., Pisaturo, M., Monari, C., Ciminelli, F., Maggi, P., Allegorico, E., Gentile, I., Sangiovanni, V., Esposito, V., Gentile, V., Calabria, G., Pisapia, R., Carriero, C., Masullo, A., Manzillo, E., Russo, G., Parrella, R., Dell’Aquila, G., Gambardella, M., ... Coppola, N., on behalf of the CoviCamp Group. (2023). Prognostic Value of Creatinine Levels at Admission on Disease Progression and Mortality in Patients with COVID-19—An Observational Retrospective Study. Pathogens, 12(8), 973. https://doi.org/10.3390/pathogens12080973

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