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Pathogens
Volume 12
Issue 8
10.3390/pathogens12081013
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Background:
Communication

HPV16 Impacts NHERF2 Expression in Oropharyngeal Cancers

by
Lucija Lulić
1,
Antonia Jakovčević
2,
Iva Kovačić
1,
Luka Manojlović
3,
Emil Dediol
4,
Josipa Skelin
1 and
Vjekoslav Tomaić
1,*
1
Division of Molecular Medicine, Ruđer Bošković Institute, Bijenička 54, 10000 Zagreb, Croatia
2
Clinical Department of Pathology and Cytology, University Hospital Center Zagreb, 10000 Zagreb, Croatia
3
Department of Pathology and Cytology, University Hospital Dubrava, 10000 Zagreb, Croatia
4
Department of Maxillofacial Surgery, University Hospital Dubrava, 10000 Zagreb, Croatia
*
Author to whom correspondence should be addressed.
Pathogens 2023, 12(8), 1013; https://doi.org/10.3390/pathogens12081013
Submission received: 2 June 2023 / Revised: 26 July 2023 / Accepted: 28 July 2023 / Published: 3 August 2023
(This article belongs to the Special Issue Pathogens in 2023)
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Abstract

Infection with human papillomaviruses (HPVs), in particular with HPV type 16, is now considered to be a key risk factor for the development of a subset of oropharyngeal squamous cell carcinomas (OPSCC) that show different epidemiological, clinical, and prognostic characteristics from HPV-negative (HPV−) OPSCCs. So far, extensive research efforts aiming to distinguish these two distinct entities have not identified specific biomarkers, nor led to different therapies. Previous research has shown that HPV16 E6 oncoprotein binds NHERF2, inducing its proteasomal degradation, and consequently increasing cell proliferation; we therefore aimed to investigate how this might be reflected in human histological samples. We analyzed NHERF2 expression patterns in HPV16-positive (HPV16+) and HPV− OPSCC samples, to investigate any potential differences in NHERF2 pattern. Interestingly, we observed a statistically significant decrease in NHERF2 levels in HPV16+ and poorly differentiated HPV− OPSCCs, compared with healthy tissue. Furthermore, we observed a significant reduction in the percentage of NHERF2 immunoreactive cancer cells in HPV16+ tumors, compared with well and moderately differentiated HPV− OPSCCs, suggesting the importance of 16E6’s targeting of NHERF2 in HPV-driven oncogenesis in the head and neck area.
Keywords: HNSCC; OPSCC; HPV; E6; p16; NHERF2 HNSCC; OPSCC; HPV; E6; p16; NHERF2

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MDPI and ACS Style

Lulić, L.; Jakovčević, A.; Kovačić, I.; Manojlović, L.; Dediol, E.; Skelin, J.; Tomaić, V. HPV16 Impacts NHERF2 Expression in Oropharyngeal Cancers. Pathogens 2023, 12, 1013. https://doi.org/10.3390/pathogens12081013

AMA Style

Lulić L, Jakovčević A, Kovačić I, Manojlović L, Dediol E, Skelin J, Tomaić V. HPV16 Impacts NHERF2 Expression in Oropharyngeal Cancers. Pathogens. 2023; 12(8):1013. https://doi.org/10.3390/pathogens12081013

Chicago/Turabian Style

Lulić, Lucija, Antonia Jakovčević, Iva Kovačić, Luka Manojlović, Emil Dediol, Josipa Skelin, and Vjekoslav Tomaić. 2023. "HPV16 Impacts NHERF2 Expression in Oropharyngeal Cancers" Pathogens 12, no. 8: 1013. https://doi.org/10.3390/pathogens12081013

APA Style

Lulić, L., Jakovčević, A., Kovačić, I., Manojlović, L., Dediol, E., Skelin, J., & Tomaić, V. (2023). HPV16 Impacts NHERF2 Expression in Oropharyngeal Cancers. Pathogens, 12(8), 1013. https://doi.org/10.3390/pathogens12081013

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