Next Article in Journal
Assessing the Operational Feasibility of Integrating Point-of-Care G6PD Testing into Plasmodium vivax Malaria Management in Vietnam
Next Article in Special Issue
Risk Factors for Hepatitis E Virus Infection and Eating Habits in Kidney Transplant Recipients
Previous Article in Journal
Investigating the Current Status of SARS-CoV-2 Antibodies in Hospital Staff
Previous Article in Special Issue
Detection of HEV RNA Using One-Step Real-Time RT-PCR in Farrow-to-Finish Pig Farms in Bulgaria
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Pathogens
Volume 12
Issue 5
10.3390/pathogens12050687
pathogens-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

First Report on Abnormal Renal Function in Acute Hepatitis E Genotype 1 Infection

by
Amal A. Elkhawaga
1,
Mohamed A. El-Mokhtar
1,
Amal A. Mahmoud
2,
Wael Esmat Ali
3,
Doaa Safwat Mohamed
4,
Ayat M. Kamel
5,
Ahmed Atef Mesalam
6,
Nermien H. S. Mousa
7,
Ahmed M. Ashmawy
8,
Essam M. Abdel Aziz
9,
Ibrahim M. Sayed
1,*,†,
Haidi Karam-Allah Ramadan
10,* and
Yasmine Samy Elkholy
11
1
Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut 71515, Egypt
2
Department of Clinical Pathology, Faculty of Medicine, Assiut University, Assiut 71515, Egypt
3
Department of Clinical Pathology, Faculty of Medicine, Al-Azhar University Assuit Branch, Assiut 71524, Egypt
4
Department of Microbiology & Immunology, Faculty of Pharmacy, Sohag University, Sohag 82524, Egypt
5
Microbiology and Immunology Department, Faculty of Pharmacy, Assiut University, Assiut 71515, Egypt
6
Department of Therapeutic Chemistry, Pharmaceutical and Drug Industries Research Institute, National Research Centre (NRC), Dokki, Cairo 12622, Egypt
7
Botany & Microbiology Department, Faculty of Science, Assiut University, Assiut 71515, Egypt
8
Department of Internal Medicine, Gastroenterology and Hepatology Unit, Faculty of Medicine, Assiut University, Assiut 71515, Egypt
9
Department of Internal Medicine, Nephrology Division, Faculty of Medicine, Assiut University, Assiut 71515, Egypt
10
Department of Tropical Medicine and Gastroenterology, Faculty of Medicine, Assiut University, Assiut 71515, Egypt
11
Department of Medical Microbiology and Immunology, Faculty of Medicine, Cairo University, Cairo 12613, Egypt
 
add Show full affiliation list
 
remove Hide full affiliation list
*
Authors to whom correspondence should be addressed.
†
Present Address: Department of Biomedical and Nutritional Sciences, University of Massachusetts Lowell, Lowell, MA 01854, USA.
Pathogens 2023, 12(5), 687; https://doi.org/10.3390/pathogens12050687
Submission received: 9 April 2023 / Revised: 28 April 2023 / Accepted: 29 April 2023 / Published: 8 May 2023
(This article belongs to the Special Issue Hepatitis E Virus (HEV) Infection among Humans and Animals: Epidemiology, Clinical Characteristics, Treatment and Prevention)
Browse Figure
Versions Notes

Abstract

Impaired renal functions have been reported with Hepatitis E virus (HEV) infections, especially with genotypes 3 and 4. These complications were reported during the acute and chronic phases of infection. HEV genotype 1 causes acute infection, and the effect of HEV-1 infections on renal functions is not known. We examined the kidney function parameters in the serum of HEV-1 patients (AHE, n = 31) during the acute phase of infection. All of the included patients developed an acute self-limiting course of infection, without progression to fulminant hepatic failure. We compared the demographic, laboratory, and clinical data between AHE patients with normal kidney function parameters and those with abnormal renal parameters. Out of 31 AHE patients, 5 (16%) had abnormal kidney function tests (KFTs) during the acute phase of infection. Three patients had abnormal serum urea and creatinine, and two patients had either abnormal urea or creatinine. Four out of five patients had an estimated glomerular filtration rate (eGFR) below 60 mL/min/1.73 m2. AHE patients with abnormal KFTs were older and had a lower level of albumin, but a slightly elevated alanine transaminase (ALT) compared to AHE patients with normal KFTs. There were no significant differences between the two groups in terms of age, sex, liver transaminase levels, and the viral load. Similarly, the clinical presentations were comparable in both groups. Interestingly, these KFTs in patients with abnormal renal parameters returned to normal levels at the recovery. The serum creatinine level was not correlated with patients’ age or liver transaminase levels, but it was significantly negatively correlated with albumin level. In conclusion, this study is the first report that evaluated KFTs in patients during the acute phase of HEV-1 infections. Impaired KFTs in some AHE patients resolved at convalescence. KFTs and renal complications should be monitored during HEV-1 infections.
Keywords: HEV; kidney function test; acute infection; genotype 1; recovery; renal disorders HEV; kidney function test; acute infection; genotype 1; recovery; renal disorders

Share and Cite

MDPI and ACS Style

Elkhawaga, A.A.; El-Mokhtar, M.A.; Mahmoud, A.A.; Ali, W.E.; Mohamed, D.S.; Kamel, A.M.; Mesalam, A.A.; Mousa, N.H.S.; Ashmawy, A.M.; Abdel Aziz, E.M.; et al. First Report on Abnormal Renal Function in Acute Hepatitis E Genotype 1 Infection. Pathogens 2023, 12, 687. https://doi.org/10.3390/pathogens12050687

AMA Style

Elkhawaga AA, El-Mokhtar MA, Mahmoud AA, Ali WE, Mohamed DS, Kamel AM, Mesalam AA, Mousa NHS, Ashmawy AM, Abdel Aziz EM, et al. First Report on Abnormal Renal Function in Acute Hepatitis E Genotype 1 Infection. Pathogens. 2023; 12(5):687. https://doi.org/10.3390/pathogens12050687

Chicago/Turabian Style

Elkhawaga, Amal A., Mohamed A. El-Mokhtar, Amal A. Mahmoud, Wael Esmat Ali, Doaa Safwat Mohamed, Ayat M. Kamel, Ahmed Atef Mesalam, Nermien H. S. Mousa, Ahmed M. Ashmawy, Essam M. Abdel Aziz, and et al. 2023. "First Report on Abnormal Renal Function in Acute Hepatitis E Genotype 1 Infection" Pathogens 12, no. 5: 687. https://doi.org/10.3390/pathogens12050687

APA Style

Elkhawaga, A. A., El-Mokhtar, M. A., Mahmoud, A. A., Ali, W. E., Mohamed, D. S., Kamel, A. M., Mesalam, A. A., Mousa, N. H. S., Ashmawy, A. M., Abdel Aziz, E. M., Sayed, I. M., Ramadan, H. K.-A., & Elkholy, Y. S. (2023). First Report on Abnormal Renal Function in Acute Hepatitis E Genotype 1 Infection. Pathogens, 12(5), 687. https://doi.org/10.3390/pathogens12050687

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop