Integrating the Gut Microbiome and Stress-Diathesis to Explore Post-Trauma Recovery: An Updated Model

Mittinty, Manasi Murthy; Lee, Joshua Y.; Walton, David M.; El-Omar, Emad M.; Elliott, James M.

doi:10.3390/pathogens11070716

Open AccessArticle

Integrating the Gut Microbiome and Stress-Diathesis to Explore Post-Trauma Recovery: An Updated Model

by

Manasi Murthy Mittinty

^1,*,†

,

Joshua Y. Lee

^2,†,

David M. Walton

²,

Emad M. El-Omar

³ and

James M. Elliott

^4,5,6

¹

Faculty of Medicine and Health, University of Sydney, Sydney, NSW 2065, Australia

²

School of Physical Therapy, Western University, London, ON N6G 1H1, Canada

³

UNSW Microbiome Research Centre, St George and Sutherland Clinical Campuses, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW 2052, Australia

⁴

School of Health Sciences, Faculty of Medicine and Health, The Kolling Institute, The University of Sydney, Sydney, NSW 2065, Australia

⁵

The Northern Sydney Local Health District, Sydney, NSW 2006, Australia

⁶

Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA

^*

Author to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Pathogens 2022, 11(7), 716; https://doi.org/10.3390/pathogens11070716

Submission received: 3 May 2022 / Revised: 10 June 2022 / Accepted: 16 June 2022 / Published: 23 June 2022

Download

Browse Figure

Review Reports Versions Notes

Abstract

Musculoskeletal conditions of traumatic and non-traumatic origin represent an ongoing health challenge. While the last three decades have seen significant advancement in our understanding of musculoskeletal conditions, the mechanisms of a delayed or lack of recovery are still a mystery. Here, we present an expansion of the integrated stress-diathesis model through the inclusion of the gut microbiome. Connecting the microbiome with known adverse neurobiologic, microbiologic and pathophysiologic sequelae following an injury, trauma or stressful event may help improve our knowledge of the pathogenesis of poor recovery. Such knowledge could provide a foundation for the exploration and development of more effective interventions to prevent the transition from acute to chronic pain.

Keywords: musculoskeletal conditions; gut microbiome; gut flora; traumatic injury; stress

Share and Cite

MDPI and ACS Style

Mittinty, M.M.; Lee, J.Y.; Walton, D.M.; El-Omar, E.M.; Elliott, J.M. Integrating the Gut Microbiome and Stress-Diathesis to Explore Post-Trauma Recovery: An Updated Model. Pathogens 2022, 11, 716. https://doi.org/10.3390/pathogens11070716

AMA Style

Mittinty MM, Lee JY, Walton DM, El-Omar EM, Elliott JM. Integrating the Gut Microbiome and Stress-Diathesis to Explore Post-Trauma Recovery: An Updated Model. Pathogens. 2022; 11(7):716. https://doi.org/10.3390/pathogens11070716

Chicago/Turabian Style

Mittinty, Manasi Murthy, Joshua Y. Lee, David M. Walton, Emad M. El-Omar, and James M. Elliott. 2022. "Integrating the Gut Microbiome and Stress-Diathesis to Explore Post-Trauma Recovery: An Updated Model" Pathogens 11, no. 7: 716. https://doi.org/10.3390/pathogens11070716

APA Style

Mittinty, M. M., Lee, J. Y., Walton, D. M., El-Omar, E. M., & Elliott, J. M. (2022). Integrating the Gut Microbiome and Stress-Diathesis to Explore Post-Trauma Recovery: An Updated Model. Pathogens, 11(7), 716. https://doi.org/10.3390/pathogens11070716

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Menu

Integrating the Gut Microbiome and Stress-Diathesis to Explore Post-Trauma Recovery: An Updated Model

Abstract

Share and Cite

Article Metrics

Article Access Statistics

Further Information

Guidelines

MDPI Initiatives

Follow MDPI