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Volume 11
Issue 7
10.3390/pathogens11070715
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Review

Review on Bovine Tuberculosis: An Emerging Disease Associated with Multidrug-Resistant Mycobacterium Species

by
Mohamed Borham
1,
Atef Oreiby
2,
Attia El-Gedawy
3,
Yamen Hegazy
2,
Hazim O. Khalifa
4,5,6,*,
Magdy Al-Gaabary
2 and
Tetsuya Matsumoto
4,*
1
Bacteriology Department, Animal Health Research Institute Matrouh Lab, Matrouh 51511, Egypt
2
Department of Animal Medicine (Infectious Diseases), Faculty of Veterinary Medicine, Kafrelsheikh University, Kafr El-Sheik 33516, Egypt
3
Bacteriology Department, Animal Health Research Institute, Giza 12618, Egypt
4
Department of Infectious Diseases, Graduate School of Medicine, International University of Health and Welfare, Narita 286-0048, Japan
5
Department of Pharmacology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafr El-Sheikh 33516, Egypt
6
Antimicrobial Resistance Research Center, National Institute of Infectious Diseases, Higashimurayama, Tokyo 189-0002, Japan
*
Authors to whom correspondence should be addressed.
Pathogens 2022, 11(7), 715; https://doi.org/10.3390/pathogens11070715
Submission received: 7 May 2022 / Revised: 16 June 2022 / Accepted: 18 June 2022 / Published: 21 June 2022
(This article belongs to the Special Issue Immunopathogenesis and Diagnostics to Control Tuberculosis in Cattle and Wildlife)
Versions Notes

Abstract

Bovine tuberculosis is a serious infectious disease affecting a wide range of domesticated and wild animals, representing a worldwide economic and public health burden. The disease is caused by Mycobacteriumbovis and infrequently by other pathogenic mycobacteria. The problem of bovine tuberculosis is complicated when the infection is associated with multidrug and extensively drug resistant M. bovis. Many techniques are used for early diagnosis of bovine tuberculosis, either being antemortem or postmortem, each with its diagnostic merits as well as limitations. Antemortem techniques depend either on cellular or on humoral immune responses, while postmortem diagnosis depends on adequate visual inspection, palpation, and subsequent diagnostic procedures such as bacterial isolation, characteristic histopathology, and PCR to reach the final diagnosis. Recently, sequencing and bioinformatics tools have gained increasing importance for the diagnosis of bovine tuberculosis, including, but not limited to typing, detection of mutations, phylogenetic analysis, molecular epidemiology, and interactions occurring within the causative mycobacteria. Consequently, the current review includes consideration of bovine tuberculosis as a disease, conventional and recent diagnostic methods, and the emergence of MDR-Mycobacterium species.
Keywords: bovine tuberculosis; Mycobacterium bovis; multidrug resistance; animal health; diagnosis and treatment of tuberculosis bovine tuberculosis; Mycobacterium bovis; multidrug resistance; animal health; diagnosis and treatment of tuberculosis

Share and Cite

MDPI and ACS Style

Borham, M.; Oreiby, A.; El-Gedawy, A.; Hegazy, Y.; Khalifa, H.O.; Al-Gaabary, M.; Matsumoto, T. Review on Bovine Tuberculosis: An Emerging Disease Associated with Multidrug-Resistant Mycobacterium Species. Pathogens 2022, 11, 715. https://doi.org/10.3390/pathogens11070715

AMA Style

Borham M, Oreiby A, El-Gedawy A, Hegazy Y, Khalifa HO, Al-Gaabary M, Matsumoto T. Review on Bovine Tuberculosis: An Emerging Disease Associated with Multidrug-Resistant Mycobacterium Species. Pathogens. 2022; 11(7):715. https://doi.org/10.3390/pathogens11070715

Chicago/Turabian Style

Borham, Mohamed, Atef Oreiby, Attia El-Gedawy, Yamen Hegazy, Hazim O. Khalifa, Magdy Al-Gaabary, and Tetsuya Matsumoto. 2022. "Review on Bovine Tuberculosis: An Emerging Disease Associated with Multidrug-Resistant Mycobacterium Species" Pathogens 11, no. 7: 715. https://doi.org/10.3390/pathogens11070715

APA Style

Borham, M., Oreiby, A., El-Gedawy, A., Hegazy, Y., Khalifa, H. O., Al-Gaabary, M., & Matsumoto, T. (2022). Review on Bovine Tuberculosis: An Emerging Disease Associated with Multidrug-Resistant Mycobacterium Species. Pathogens, 11(7), 715. https://doi.org/10.3390/pathogens11070715

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