SARS-CoV-2 Infection Prompts IL-1β-Mediated Inflammation and Reduces IFN-λ Expression in Human Lung Tissue
Abstract
:1. Introduction
2. Materials and Methods
2.1. Case Selection
2.2. Autopsies and Tissue Processing
2.3. Histological and Immunohistochemical Analysis
2.4. Statistical Analysis
3. Results
3.1. Clinical Overview of the Enrolled Subjects
3.2. COVID-19 Patients Have Increased IL-1β Expression in Lung Tissue
3.3. IFN-λ Is Reduced in COVID-19 Patients
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Vezzani, B.; Neri, M.; D’Errico, S.; Papi, A.; Contoli, M.; Giorgi, C. SARS-CoV-2 Infection Prompts IL-1β-Mediated Inflammation and Reduces IFN-λ Expression in Human Lung Tissue. Pathogens 2022, 11, 1390. https://doi.org/10.3390/pathogens11111390
Vezzani B, Neri M, D’Errico S, Papi A, Contoli M, Giorgi C. SARS-CoV-2 Infection Prompts IL-1β-Mediated Inflammation and Reduces IFN-λ Expression in Human Lung Tissue. Pathogens. 2022; 11(11):1390. https://doi.org/10.3390/pathogens11111390
Chicago/Turabian StyleVezzani, Bianca, Margherita Neri, Stefano D’Errico, Alberto Papi, Marco Contoli, and Carlotta Giorgi. 2022. "SARS-CoV-2 Infection Prompts IL-1β-Mediated Inflammation and Reduces IFN-λ Expression in Human Lung Tissue" Pathogens 11, no. 11: 1390. https://doi.org/10.3390/pathogens11111390