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Pathogens
Volume 10
Issue 7
10.3390/pathogens10070912
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Article
Peer-Review Record

Evidence of Immune Modulators in the Secretome of the Equine Tapeworm Anoplocephala perfoliata

Pathogens 2021, 10(7), 912; https://doi.org/10.3390/pathogens10070912
by Boontarikaan Wititkornkul 1,2, Benjamin J. Hulme 1, John J. Tomes 1, Nathan R. Allen 1, Chelsea N. Davis 1, Sarah D. Davey 1, Alan R. Cookson 1, Helen C. Phillips 1, Matthew J. Hegarty 1, Martin T. Swain 1, Peter M. Brophy 1, Ruth E. Wonfor 1,*,† and Russell M. Morphew 1,*,†
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Reviewer 3: Anonymous
Pathogens 2021, 10(7), 912; https://doi.org/10.3390/pathogens10070912
Submission received: 29 June 2021 / Revised: 14 July 2021 / Accepted: 15 July 2021 / Published: 20 July 2021
(This article belongs to the Special Issue Proteomics of Host-Helminth Interactions)

Round 1

Reviewer 1 Report

Manuscript is well written and has provided very useful information for the basic science research. Authors have to make sure all the scientific names  and other latin words are italicized (This is lacking all through out the methods and results).

Author Response

We thank the reviewer for their kind comments.  We apologise for the lack of italics.  This was intially correct but has reverted to non-italics during the submission process.  All species names are now in italics as requested. Thanks again.

Reviewer 2 Report

Wititkornkul and colleagues performed a detailed molecular analysis on A. perfoliata, performing RNA sequencing and generating the first A. perfoliata transcriptome. In addition, the authors also analysed the excretory secretory products (ESP) from A. perfoliate, in particular, free proteins and extracellular vesicles (EVs). The authors presented an extensive and detailed description of several potential molecular targets on host -parasite interaction. The present work is well written and easy to follow and can be accepted for publication in its present form.

Author Response

We thank the reviewer for their time to read our work and for their very kind comments.  Best wishes.

Reviewer 3 Report

 

This comprehensive work on Anoplocephala sp. tapeworms of horses provides several valuable datasets for those in the field.  The annotated transcriptome, initial data on secreted protein molecules, and on vesicle secretion are extremely valuable to subsequent development of novel vaccines, diagnostic assays, and treatments for this parasite.  The methodology is sound, and the manuscript well-written.  I have no significant critiques. I commend the authors on such a strong submission. 

Author Response

Many thanks to the reviewer for their time to read this paper and for their extremely positive comments.  Best wishes for the future.

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